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NIPSNAP1 Rabbit pAb (bs-19252R)  
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產(chǎn)品編號 bs-19252R
英文名稱 NIPSNAP1 Rabbit pAb
中文名稱 NIPSNAP1蛋白抗體
別    名 NIPSNAP 1; Nipsnap homolog 1(C. elegans); Protein NipSnap homolog 1.  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 33 kDa
檢測分子量
細(xì)胞定位 細(xì)胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIPSNAP1: 201-284/284 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Function:
NIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6). NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP’s expression is reduced in the phenylketonuria (PKU) mouse brain, suggesting that NIPSNAP may play a role in memory.

Subcellular Location:
Mitochondrial

SWISS:
Q9BPW8

Gene ID:
8508

Database links:

Entrez Gene: 8508 Human

Entrez Gene: 18082 Mouse

Entrez Gene: 360971 Rat

Omim: 603249 Human

SwissProt: Q9BPW8 Human

SwissProt: O55125 Mouse

Unigene: 173878 Human

Unigene: 293716 Mouse

Unigene: 103205 Rat



產(chǎn)品圖片
Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti-NIPSNAP1 (bs-19252R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 33 kD
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