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RAB3IL1 Rabbit pAb (bs-19716R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
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產品編號 bs-19716R
英文名稱 RAB3IL1 Rabbit pAb
中文名稱 RAB3A相關樣蛋白1抗體
別    名 GRAB; Guanine nucleotide exchange factor for Rab 3A; guanine nucleotide exchange factor for Rab3A; Rab3A interacting like protein 1; RAB3A interacting protein(rabin3) like 1; Rabin3 like 1.  
研究領域 細胞生物  神經生物學  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 43 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAB3IL1: 131-230/382 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]

Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.

Subunit:
Interacts with RAB3A and IHPK1 through the coiled-coil domain. This interaction is competitive. IHPK1 kinase activity is not required for this interaction (By similarity).

Similarity:
Belongs to the SEC2 family.

SWISS:
Q8TBN0

Gene ID:
5866

Database links:

Entrez Gene: 5866 Human

Entrez Gene: 74760 Mouse

Entrez Gene: 171452 Rat

SwissProt: Q8TBN0 Human

SwissProt: Q8VDV3 Mouse

SwissProt: Q99NH3 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RAB3IL1) Polyclonal Antibody, Unconjugated (bs-19716R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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