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CRF Rabbit pAb (bs-41044R)  
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產品編號 bs-41044R
英文名稱 CRF Rabbit pAb
中文名稱 促腎上腺皮質激素釋放因子/促腎上皮質激素釋放激素抗體
別    名 Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included; corticoliberin preproprotein; CRF_HUMAN; Corticotropin-releasing factor; CRH1; CRH; Corticotropin-releasing hormone.  
研究領域 神經生物學  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat (predicted: Human)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 5/22 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRF: 154-194/194 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Subunit:
Interacts (via C-terminus) with CRFR1 (via N-terminalv extracellular domain).

Subcellular Location:
Secreted.

Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

SWISS:
P06850

Gene ID:
1392

Database links:

Entrez Gene: 1392 Human

Entrez Gene: 12918 Mouse

Entrez Gene: 81648 Rat

Omim: 122560 Human

SwissProt: P06850 Human

SwissProt: Q8CIT0 Mouse

SwissProt: P01143 Rat

Unigene: 75294 Human

Unigene: 290689 Mouse

Unigene: 10349 Rat



CRF陽性神經元的胞體廣泛分布于下丘腦的室旁核、背縫核和藍斑核,這些區域也是去甲腎上腺素(NE)神經元與5-羥色胺(5-HT)神經元密集的區域。
CRF既具有神經遞質的性質又具有神經激素的性質。CRF是聯系神經系統與內分泌系統的橋梁,在情感障礙疾患如焦慮和抑郁的發病中發揮重要作用.
產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with CRF polyclonal antibody, unconjugated (bs-41044R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
25 ug total protein per lane of various lysates (see on figure) probed with CRF polyclonal antibody, unconjugated (bs-41044R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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