97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
91tv在线播放网站,午夜久久久久久久久久,久久婷婷国产综合精品
首頁 > 產品中心 > 一抗 > 產品信息
IL-4R Rabbit pAb (bs-23579R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-23579R
英文名稱 IL-4R Rabbit pAb
中文名稱 白細胞介素4受體抗體
別    名 CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha.  IL-4Rα; IL 4Rα; IL-4 Rα; IL-4-Rα;
研究領域 細胞生物  免疫學  細胞膜受體  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse,Rat
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 88 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat IL-4R: 111-210/801 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Subunit:
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Post-translational modifications:
On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 1 fibronectin type-III domain.

SWISS:
Q63257

Gene ID:
25084

Database links:

Entrez Gene: 3566 Human

Entrez Gene: 16190 Mouse

Entrez Gene: 25084 Rat

Omim: 147781 Human

SwissProt: P24394 Human

SwissProt: P16382 Mouse

SwissProt: Q63257 Rat

Unigene: 513457 Human



產品圖片
Sample: Lane 1: Testis (Rat) Lysate at 40 ug Lane 2: Lymph node (Rat) Lysate at 40 ug Lane 3: Spleen (Rat) Lysate at 40 ug Primary: Anti- IL-4R (bs-23579R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 140 kD Observed band size: 135 kD
Sample: Lane 1: Lymph node (Mouse) Lysate at 40 ug Primary: Anti- IL-4R (bs-23579R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 140 kD Observed band size: 135 kD
Sample: Lane 1: Thymus (Mouse) Lysate at 40 ug Primary: Anti- IL-4R (bs-23579R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 140 kD Observed band size: 140 kD
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 9久9久9久女女女九九九一九 | 国产专区在线视频 | 三级无码AV在线观看网址 | 99视频国产精品免费观看 | 日本一级片在线观看 | 91p在线观看 | 国产精品成人av | 狂野欧美性猛交bbbb | 伊人精品在线观看 | 激情三级 | aV无码久久久久不卡蜜桃 | 国产成人涩涩涩视频在线观看 | 91精品国产自产在线观看自播 | 亚洲精品三级在线观看 | 黑人巨大精品欧美久久 | 内射少妇一区27P | 日日摸夜添夜夜夜添高潮 | 欧美午夜精品一区二区蜜桃 | 日本一区二区三区免费软件 | 日韩欧美中文免费 | 亚洲AV无码一区二区三区观看 | 成年人视频免费在线观看 | 无码人妻丰满熟妇精品区 | 91新视频在线观看 | 成年网站在线播放 | 国产精品久久久天天影视香蕉 | 女人被男人桶爽视频网站 | 国产专区免费av无码 | 一区二区三区精品视频免费播放 | 91免费进入| 天天看天天摸天天操 | 日本色中色 | 亚洲伊人久久综合影院 | 99国精产品影视 | 无码男男肉片在线观看 | 2021国产精品成人免费视频 | 蜜桃麻豆WWW久久囤产精品 | 18videossex性欧美69 | 97九色 | 免费国产女王调教在线视频 | 国产aⅴ夜夜欢一区二区三区 |