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CCR3 Rabbit pAb (bs-23671R)  
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產品編號 bs-23671R
英文名稱 CCR3 Rabbit pAb
中文名稱 細胞表面趨化因子受體3抗體
別    名 CCR-3; CC chemokine receptor 3; Chemokine(C-C motif) receptor 3; MIP-1 alpha receptor like-2; B chemokine receptor; b-chemokine receptor; C C chemokine receptor type 3; C C CKR 3; C-C chemokine receptor type 3; CC chemokine receptor type 3; CC CKR 3; CC R3; CCCKR3; CCR 3; CCR3; CCR3_MOUSE; CD 193; CD193 antigen; chemokine(C-C motif) receptor 3; Chemokine(CC) receptor 1 like 2; Chemokine CC motif receptor 3; Chemokine receptor 3; CK R3; CKR 3; CMKB R3; CMKBR 3; CMKBR1L2; CMKBR3; Eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; Eotaxin receptor; Macrophage inflammatory protein 1 alpha receptor like 2; MGC102841; MIP1 alpha RL2; Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2; MIP-1 alpha RL2; CD193.  
研究領域 腫瘤  免疫學  信號轉導  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Rat)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 41 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CCR3: 131-230/355 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3(CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.

Function:
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Subunit:
Binds to HIV-1 Tat.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
In eosinophils as well as trace amounts in neutrophils and monocytes.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P51678

Gene ID:
12771

Database links:

Entrez Gene: 1232 Human

Entrez Gene: 12771 Mouse

Entrez Gene: 117027 Rat

Omim: 601268 Human

SwissProt: P51677 Human

SwissProt: P51678 Mouse

SwissProt: O54814 Rat

Unigene: 506190 Human

Unigene: 57050 Mouse

Unigene: 9890 Rat



產品圖片
Sample: Lane 1: Mouse Lymph node tissue lysates Lane 2: Mouse Lung tissue lysates Primary: Anti-CCR3 (bs-23671R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kDa Observed band size: 59 kDa
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