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P2RX1 Rabbit pAb (bs-21358R)  
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50ul/1180.00元
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產品編號 bs-21358R
英文名稱 P2RX1 Rabbit pAb
中文名稱 三磷酸腺苷受體受體P2X1抗體
別    名 P2X1; ATP receptor; ATP receptor; H sapiens mRNA for ATP receptor; H.sapiens mRNA for ATP receptor; P2 RX1; P2RX1; P2RX1 protein; P2RX1_HUMAN; P2X purinoceptor 1; P2X receptor subunit 1; P2X1; P2X1 receptor; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 1; Purinergic receptor P2X ligand-gated ion channel 1; Purinergic receptor P2X1.  
研究領域 心血管  細胞生物  細胞凋亡  通道蛋白  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Cow)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 45 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human P2RX1 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.

Function:
Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.

Subunit:
Homo- or heteropolymers (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the P2X receptor family.

SWISS:
P51575

Gene ID:
5023

Database links:
Entrez Gene: 5023 Human

Entrez Gene: 18436 Mouse

Entrez Gene: 25505 Rat

Omim: 600845 Human

SwissProt: P51575 Human

SwissProt: P51576 Mouse

SwissProt: P47824 Rat

Unigene: 41735 Human

Unigene: 25722 Mouse

Unigene: 91176 Rat



產品圖片
Sample: Urinary bladder (Mouse) Lysate at 40 ug Penis (Mouse) Lysate at 40 ug Primary: Anti- P2RX1 (bs-21358R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kD Observed band size: 65 kD
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