97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
亚洲女v,久久av影视,免费a在线播放
首頁 > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
[KO驗證抗體] Erk2 Mouse mAb (bsm-51555M)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
大包裝/詢價

產(chǎn)品編號 bsm-51555M
英文名稱 [KO驗證抗體] Erk2 Mouse mAb
中文名稱 絲裂原活化蛋白激酶2/ERK2單克隆抗體
別    名 ERK 2; ERK-2; ERT1; Extracellular Signal Regulated Kinase 2; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; Mapk1; Mitogen-activated protein kinase 1; MK01_HUMAN; P38; P40; P41; p42-MAPK; P42MAPK; PRKM1; PRKM2; protein kinase, mitogen-activated, 1; protein kinase, mitogen-activated, 2; protein tyrosine kinase ERK2.  
研究領域 腫瘤  細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  干細胞  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細胞骨架  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 D2F12
交叉反應 Human,Mouse,Rat (predicted: Cow,Xenopus)
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 42 kDa
檢測分子量
細胞定位 細胞核 細胞漿 細胞膜 細胞外基質(zhì) 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Erk2: 101-200/360 
亞    型 IgG1,k
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

Subcellular Location:
Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Note=Associated with the spindle duringprometaphase and metaphase. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Note=Associated with the spindle during prometaphase and metaphase. PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylated upon KIT and FLT3 signaling. Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs. Dephosphorylated by DUSP1 at Thr-185 and Tyr-187.
ISGylated.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

SWISS:
P28482

Gene ID:
5594

Database links:

Entrez Gene: 5594 Human

Entrez Gene: 26413 Mouse

Entrez Gene: 116590 Rat

Omim: 176948 Human

SwissProt: P28482 Human

SwissProt: P63085 Mouse

SwissProt: P63086 Rat



產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with ERK2 monoclonal antibody, unconjugated (bsm-51555M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产欧美一区二区白浆黑人 | 国产AV午夜精品一区二区入口 | 国外AV无码精品国产精品 | 火影大胸美女被黄网站 | 国产丝袜一区视频在线观看 | 亚洲天堂精品在线观看 | 国产精品久久久久久久久久了 | 日本不卡一区二区三区 | 国产精华最好的产品有哪些 | 人人澡人人曰人人摸看 | 久久久一区二区三区 | 成人性生交无码免费看 | av爽爽| 国产九色视频在线观看 | 日韩视频一区在线观看 | 麻豆国产人妻精品无码AV | 中文字幕国内自拍 | 久久精品在线 | 最近中文字幕免费MV在线视频 | 国产www免费| 999久久久国产精品消防器材 | 在线欧美成人 | 免费看一级黄色 | 亚洲日本乱码一区二区三区 | 每日更新在线观看AV_手机 | 制服丝袜中文字幕无码自拍 | 床震吃胸膜奶免费视频 | 亚洲人亚洲人色久 | 一道本不卡视频 | 久久精品一区二区三区四区 | 国产无套激情在线视频 | 亚洲xxxx3d | 狠狠色婷婷久久一区二区三区91 | GOGOGO免费高清视频3 | 国产福利视频网站 | 女人看片www.8888成人 | 成人欧美大片免费观看 | 视频一区视频二区视频 | 色老头av亚洲一区二区男男 | 欧美激情网站在线观看 | 日韩成人区 |