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RAB1B Mouse mAb (bsm-51615M)  
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50ul/1180.00元
100ul/1980.00元
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產品編號 bsm-51615M
英文名稱 RAB1B Mouse mAb
中文名稱 RAB1B單克隆抗體
別    名 RAB1B member RAS oncogene family; RAB1B_HUMAN; Ras related protein Rab1B; Ras-related protein Rab-1B; Small GTP binding protein.  
研究領域 信號轉導  G蛋白信號  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 C7D12
交叉反應 Human,Mouse,Rat
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 22 kDa
檢測分子量
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant human RAB1B between 1-201 amino acids. 
亞    型 IgG1,k
純化方法 affinity purified by Protein G
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

Function:
Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.

Subcellular Location:
Membrane. Cytoplasm. Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.

Post-translational modifications:
Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1). AMPylation at Tyr-77 occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively active.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

SWISS:
Q9H0U4

Gene ID:
81876

Database links:

Entrez Gene: 81876 Human

SwissProt: Q9H0U4 Human



產品圖片
Sample: Lane 1: Hela cell lysates Lane 2: A431 cell lysates Lane 3: U-20S cell lysates Lane 4: Rat liver tissue lysates Lane 5: NIH/3T3 cell lysates Primary: Anti-RAB1B (bsm-51615M) at 1/4000 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 25 kD
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