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BDKRB1 Rabbit pAb (bs-24921R)  
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產品編號 bs-24921R
英文名稱 BDKRB1 Rabbit pAb
中文名稱 緩激肽B1受體抗體
別    名 B1 bradykinin receptor; B1BKR; B1R; BDKR B1; BDKRB 1; BDKRB1; BK 1 receptor; BK-1 receptor; bradykinin B1 R; BKB1R; BKR 1; BKR1; BKRB1_HUMAN; BRADY B1; BRADYB1; Bradykinin B1 receptor; Bradykinin receptor 1; bradykinin B1R; Bradykinin receptor B1  
研究領域 腫瘤  免疫學  信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 40 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BDKRB1: 281-353/353 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.

Function:
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Subunit:
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Subcellular Location:
Cell membrane.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

SWISS:
P46663

Gene ID:
623

Database links:

Entrez Gene: 623 Human

Omim: 600337 Human

SwissProt: P46663 Human

Unigene: 525572 Human



產品圖片
Sample: Lane 1: Human Siha cell lysates Lane 2: Human Lovo cell lysates Lane 3: Human K562 cell lysates Lane 4: Human A549 cell lysates Lane 5: Human Hela cell lysates Primary: Anti-BDKRB1 (bs-24921R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 60 kD
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