97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
嫩草亚洲,中文在线字幕免费观看,国产精品一区二区毛片
首頁(yè) > 產(chǎn)品中心 > 一抗 > 產(chǎn)品信息
APEX1 Recombinant Rabbit mAb (bsm-60707R)  
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
25ul/800.00元
50ul/1400.00元
100ul/2500.00元
大包裝/詢價(jià)

產(chǎn)品編號(hào) bsm-60707R
英文名稱 APEX1 Recombinant Rabbit mAb
中文名稱 多功能DNA修復(fù)酶重組兔單抗
別    名 APEX1_HUMAN; DNA-(apurinic or apyrimidinic site) endonuclease; EC:3.1.11.2; APE; APE1; APEX; APX; HAP1; REF1; APEX nuclease(APEN); Apurinic-apyrimidinic endonuclease 1(AP endonuclease 1; APE-1); REF-1; Redox factor-1; DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial;  
研究領(lǐng)域 心血管  染色質(zhì)和核信號(hào)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Recombinant
克 隆 號(hào) R2D12
交叉反應(yīng) Human,Mouse,Rat
產(chǎn)品應(yīng)用 WB=1:1000-5000,IHC-P=1:100-500,IHC-F=1:200-500,IF=1:25
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 36 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APEX1 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019]


Subcellular Location:
Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Note=Detected in the cytoplasm of B-cells stimulated to switch. Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm.
DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion. Note=The cleaved APEX2 is only detected in mitochondria. Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress.

SWISS:
P27695

Gene ID:
328

Database links:

Entrez Gene: 328 Human

Entrez Gene: 11792 Mouse

Entrez Gene: 79116 Rat

SwissProt: P27695 Human

SwissProt: P28352 Mouse

SwissProt: P43138 Rat



產(chǎn)品圖片
Blocking buffer: 5% NFDM/TBST Primary Ab dilution: 1:5000 Primary Ab incubation condition: 2 hours at room temperature Secondary Ab: Goat Anti-Rabbit IgG H&L (HRP) Lysate: 1: HEK-293, 2: HepG2, 3: NIH/3T3, 4: RAW264.7 Protein loading quantity: 20 μg Exposure time: 60 s Predicted MW: 35 kDa Observed MW: 37 kDa
Tissue: Rat liver Section type: Formalin-fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:1000 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for bsm-60707R
Tissue: Mouse liver Section type: Formalin-fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:1000 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for bsm-60707R
Tissue: Human ovarian carcinoma Section type: Formalin-fixed & Paraffin - embedded section Retrieval method: High temperature and high pressure Retrieval buffer: Tris/EDTA buffer, pH 9.0 Primary Ab dilution: 1:1000 Primary Ab incubation condition: 1 hour at room temperature Secondary Ab: Anti-Rabbit and Mouse Polymer HRP (Ready to use) Counter stain: Hematoxylin (Blue) Comment: Color brown is the positive signal for bsm-60707R
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 免费国产视频 | 国产乱对白刺激视频在线观看 | 欧美日韩激情一区二区 | 黄色一级日本 | 暴力调教一区二区三区 | 国产v精品成人免费视频400条 | 日本一区免费看 | 国产精品麻豆 | 三区影院 | 免费看毛片网站 | 成人午夜看片网址 | 欧美日韩一级在线 | 国产清纯91天堂在线观看 | 69堂免费视频| 国产一区二区三区综合 | 久久99蜜桃综合影院免费观看 | 视频一区视频二区视频 | YW尤物AV无码国产在线观看 | 精品欧美一区二区中文字幕视频 | 日韩福利在线视频 | 久久综合九色综合97网 | 欧美一区二区三区久久精品视 | 一女被两男吃奶玩乳尖 | aaaa国产 | 亚洲中文无码成人影院 | 伦理片一区二区三区 | 亚洲成年人网站在线观看 | 狠狠干狠狠操视频 | 免费看a | 欧美视频国产 | 人人爱人人做 | 欧美不卡一区 | 久久日韩激情一区二区三区四区 | 毛片无码一区二区三区a片视频 | av视屏| 野花社区免费观看视频高清 | 无码日韩精品一区二区免费 | 艳妇荡乳豪妇荡乳av精东 | 在线免费观看一区二区 | 天天舔夜夜操 | 亚洲日产色情偷拍 |