| 產(chǎn)品編號 | bsm-63299R |
| 英文名稱 | phospho-Tuberin (S939) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化馬鈴薯球蛋白(結(jié)節(jié)性硬化)重組兔單抗 |
| 別 名 | PPP1R160; tsc2; TSC4; Tuberin. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 5D7 |
| 交叉反應(yīng) | Human,Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 201 kDa |
| 檢測分子量 | 200 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Tuberin around the phosphorylation site of S939: RST-pS-LNER |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. SWISS: P49815 Gene ID: 7249 Tuberin 為180kD-220的蛋白產(chǎn)生于結(jié)節(jié)性硬化（TSC-2）位于染色體16的基因。結(jié)節(jié)性硬化為常染色體疾病已知為斑痣性錯構(gòu)瘤病其特征為廣泛性發(fā)展呈良性生長，在許多組織與器官中描述為錯構(gòu)瘤。Tuberin被認(rèn)為在GTPase活動性蛋白中起作用調(diào)節(jié)細(xì)胞內(nèi)吞與作為腫瘤抑制子。Tuberin低水平廣泛性表達(dá)在大多數(shù)組織中，而在皮層神經(jīng)元、小腦浦肯野氏細(xì)胞、脊索運(yùn)動神經(jīng)元、胰島B細(xì)胞、心肌、腎臟與皮膚的小血管中表達(dá)增加。 |
