97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
99久E在线精品视频在线,2022中文字幕,人人爽人人看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-RIN1/FITC Conjugated antibody (bs-6094R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6094R-FITC
英文名稱 Rabbit Anti-RIN1/FITC Conjugated antibody
中文名稱 FITC標記的RAS互動/干擾蛋白1抗體
別    名 Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質(zhì)和核信號  神經(jīng)生物學  信號轉(zhuǎn)導  G蛋白偶聯(lián)受體  表觀遺傳學  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.

Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Subunit:
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

Subcellular Location:
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Tissue Specificity:
Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Post-translational modifications:
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.

Similarity:
Belongs to the RIN (Ras interaction/interference) family.
Contains 1 Ras-associating domain.
Contains 1 SH2 domain.
Contains 1 VPS9 domain.

Database links:

Entrez Gene: 9610 Human

Entrez Gene: 225870 Mouse

Entrez Gene: 207119 Rat

Omim: 605965 Human

SwissProt: Q13671 Human

SwissProt: Q921Q7 Mouse

SwissProt: P97680 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 人人爽人人澡人人高潮 | 亚洲高清视频在线 | mdmf.tv麻豆| 精品国偷自产在线视频 | 九九热线视频只有这里最精品 | 水野优香在线亚洲一区 | 精品久久久久久久人人人人传媒 | 久久精品亚洲成在人线av麻豆 | www.夜夜 | 欧美成人午夜 | 青天衙门高清第一部免费观看 | 高潮毛片免费观看 | 亚洲综合在线一区 | 精国产品一区二区三区a片 无码专区AAAAAA免费视频 | 五月丁香综合激情六月久久 | 亚洲精品亚洲人成在线观看麻豆 | 日韩欧美小视频 | 免费看av毛片多人群伦 | 国产暴力强伦轩1区二区小说 | 99久e精品热线免费 狠狠躁夜夜a产精品视频 | 91中文| 绿巨人在线观看免费观看在线nba动漫 | av免费播放网址 | 久久的色 | 国产最新福利 | 精品久久久国产 | 毛片a在线| 男男GAY亚洲帅哥在线 | 久久99精品久久久久久久久久 | 国产三级精品三级在 | 青青草视频精品 | 国产午夜精品片一区二区三区 | 日韩AV一中美AV一中文字慕 | 可以免费观看av毛片 | 亚洲日日摸夜夜夜夜夜爽小说 | 日日躁夜夜躁aaaaxxxx | 欧美综合一区 | 青青草激情视频 | 日本伊人精品一区二区三区观看方式 | 综合色天天鬼久久鬼色 | 国产欧美一区二区三区视频 |