97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
天堂аⅴ在线最新版在线,热久久这里都是精品,在教室里揉老师的胸动态图
Rabbit Anti-RIN1/Cy5 Conjugated antibody (bs-6094R-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6094R-Cy5
英文名稱 Rabbit Anti-RIN1/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的RAS互動(dòng)/干擾蛋白1抗體
別    名 Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1.   
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  表觀遺傳學(xué)  G蛋白信號(hào)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.

Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Subunit:
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

Subcellular Location:
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Tissue Specificity:
Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Post-translational modifications:
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.

Similarity:
Belongs to the RIN (Ras interaction/interference) family.
Contains 1 Ras-associating domain.
Contains 1 SH2 domain.
Contains 1 VPS9 domain.

Database links:

Entrez Gene: 9610 Human

Entrez Gene: 225870 Mouse

Entrez Gene: 207119 Rat

Omim: 605965 Human

SwissProt: Q13671 Human

SwissProt: Q921Q7 Mouse

SwissProt: P97680 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 女人下边被添全过程A片 | 中日韩一级视频 | 男人影音 | 优酷在线观看 | 亚洲自拍偷拍欧美 | 国内黄色大片 | 三年片在线观看免费大全 | 国产偷久久一级精品 | 国产精品人人爽人人做av片 | 日本最新在线观看一区二区三区 | 国产亚洲AV人片在线观看 | 无码aⅴ免费中文字幕久久 国产精品1234 | 成人免费A级毛片无码片2023 | 色爱综合网中文字幕第1页 国产农村妇女毛片精品久久 | 久久精品无码AV | 99久久免费精品国产72精品九九 | 东京热无码av一区二区 | 一区二区三区在线免费 | 香蕉久久综合 | 伊人中文字幕在线观看 | 免费一区二区三区在线观看 | 国产精品99久久久久久久 | 久久久视屏 | 日本不卡一区二区三区四区 | AV无码岛国免费动作片 | 久久久精品久久 | 一区av在线 | 亚洲色图88 | 精品无码一区二区三区在线 | 人人鲁免费播放视频 | 成人毛片在线 | 欧美做受又硬又粗又大视频 | 精品一二三区久久aaa片 | 国产亚洲AV夜间福利香蕉149 | 欧美精产国品一二三产品区别在哪 | 亚洲中文无码成人手机版 | 国产亚洲第一伦理片在线c 啪啪网址大全 | 爱福利在线视频 | 人人妻人人爽人人做夜欢视频九色 | 欧美日韩一区二区精品 | 动漫精品视频一区二区三区 |