97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
韩国一级片中文字幕,四虎精品8848ys一区二区,天操天天干
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RIN1/BF555 Conjugated antibody (bs-6094R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6094R-BF555
英文名稱 Rabbit Anti-RIN1/BF555 Conjugated antibody
中文名稱 BF555標記的RAS互動/干擾蛋白1抗體
別    名 Ras and Rab interactor 1; ras inhibitor 1; ras inhibitor; RIN1_HUMAN; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN 1.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質和核信號  神經生物學  信號轉導  G蛋白偶聯受體  表觀遺傳學  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RIN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
RIN1 is a Ras effector protein which can affect Ras signaling in a variety of ways. It enhances signaling from ABL1 and ABL2 whcih are involved in regulation of cytoskeletal remodeling. It may function as a guanine nucleotide exchange factor in activation of Rab5a. Rin1 also competes with RAF1 for binding of the activated form of Ras. It may play a role inhibiting the modulation of neuronal plasticity in formation of aversive memory, and has been implicated as a tumor supressor gene in breast cancer.

Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Subunit:
Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

Subcellular Location:
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Tissue Specificity:
Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Post-translational modifications:
Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.

Similarity:
Belongs to the RIN (Ras interaction/interference) family.
Contains 1 Ras-associating domain.
Contains 1 SH2 domain.
Contains 1 VPS9 domain.

Database links:

Entrez Gene: 9610 Human

Entrez Gene: 225870 Mouse

Entrez Gene: 207119 Rat

Omim: 605965 Human

SwissProt: Q13671 Human

SwissProt: Q921Q7 Mouse

SwissProt: P97680 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精成人品日日拍夜夜免费 | 国产亚洲视频网站 | 久久国产午夜精品理论片推荐 | 亚洲激情免费 | 成人网免费在线观看 | 亚洲乱码一二三四区 | 男女性色大片免费网站 | 色情久久久AV熟女人妻网站 | 久久精品成人一区二区三区 | 黄色免费看片 | 久国久产久精永久网页 | 日本高清一二区 | 国产无遮挡色视频免费观看性色 | 免费黄色av片 | 日韩精品在线一区二区 | 国产欧美一区二区精品三级 | 成人国产在线观看 | 亚洲乱码一区二区三区四区 | 精品乱码一区内射人妻无码 | 93超碰国产大屁股 | 亚洲美女久久久 | 亚洲国产成人精品福利在线观看 | 4438成人网| 久久久日韩精品一区二区 | 91亚洲一区二区 | 亚洲一区二区三区久久 | 中文字幕在线中文字幕二区 | 国产一区二区精品久 | 九九一级片 | 色婷婷五月综合激情中文字幕 | 国产精品99久久久久久小说 | 精品少妇爆乳无码av无码专区 | yellow视频在线观看免费 | 欧美顶级毛片在线看 | 91tv官网精品成人亚洲 | 亚洲精品456在线播放第一页 | 天天躁日日躁狠狠躁欧美老妇小说 | 日本中文字幕在线免费观看视频 | 国产三级午夜理伦三级最新章节 | 午煮香蕉小辣椒 | 国产电视伦理怡红院在线观看 |