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Rabbit Anti-Rho GTPase activating protein 29/RBITC Conjugated antibody (bs-6098R-RBITC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6098R-RBITC
英文名稱 Rabbit Anti-Rho GTPase activating protein 29/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的Rho GTP酶激活蛋白29抗體
別    名 ARHGAP 29; ARHGAP29; ARHGAP29 protein; MGC166097; PARG 1; PARG1; PTPL1 associated RhoGAP 1; PTPL1-associated RhoGAP protein 1; RHG29_HUMAN; Rho GTPase acti ating protein 29; Rho GTPase acti ating protein 29 isoform CRA_a; Rho GTPase acti ating protein 29 isoform CRA_b; Rho GTPase-acti ating protein 29; Rho-type GTPase-acti ating protein 29.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  信號轉導  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 142kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PARG1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Rho GTPase activating protein 29 is a GTPase activator for the Rho-type GTPases. It converts them to an inactive GDP-bound state. It has strong activity toward RHOA and weaker activity toward RAC1 and CDC42. It also may act as a specific effector of RAP2A to regulate Rho. There are two named isoforms produced by alternative splicing. Rho GTPase activating protein 29 is widely expressed; highly expressed in skeletal muscle and heart; expressed at intermediate level in placenta, liver and pancreas; weakly expressed in brain, lung and kidney.

Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.

Subunit:
Interacts with PTPN13/PTPL1. Interacts with RAP2A via its coiled coil domain. Interacts with RASIP1 (By similarity).

Tissue Specificity:
Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney.

Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Rho-GAP domain.

Database links:
UniProtKB/Swiss-Prot: Q52LW3.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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