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Rabbit Anti-GPR124/Gold Conjugated antibody (bs-6150R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-6150R-Gold
英文名稱 Rabbit Anti-GPR124/Gold Conjugated antibody
中文名稱 膠體金標記的G蛋白偶聯(lián)受體124抗體(腫瘤血管內皮標記物)
別    名 TEM5; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein coupled receptor 124; G-protein coupled receptor 124; GP124_HUMAN; GPR 124; GPR124; KIAA1531; TEM 5; TEM5; Tumor endothelial marker 5; Tumor endothelial marker 5 precursor.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  細胞生物  免疫學  信號轉導  血管內皮細胞  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 139kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPR124
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Tumor endothelial markers (TEMs) display elevated expression during angiogenesis. Their associations with the cell surface membrane are of great interest for both biological and clinical research. G protein coupled receptor 124 (GPR124) is encoded as a seven pass transmembrane protein of 1331 amino acids and is most similar to the cadherin related Celsr1 proteins and members of the calcium independent alpha latrotoxin receptor family involved in transmitting signals across the cell membrane. GPCRs have been excellent drug targets because their natural ligands can often mimicked for agonistic or antagonistic purpose. The existence of tumour specific endothelial markers provides a resource for further understanding the mechanisms of tumour angiogenesis and encourages the development of antiangiogenic therapies in the future. ESTs for the gene that encodes GPR124 have been isolated primarily from amnion, connective tissue, ear, embryo, eye, ganglion, heart, lung, placenta, and skin libraries.

Function:
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).

Subunit:
Interacts with DLG1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 25960 Human

Entrez Gene: 78560 Mouse

Entrez Gene: 306543 Rat

Omim: 606823 Human

SwissProt: Q96PE1 Human

SwissProt: Q91ZV8 Mouse

Unigene: 274136 Human

Unigene: 87046 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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