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Rabbit Anti-KIST/AP Conjugated antibody (bs-6260R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6260R-AP
英文名稱 Rabbit Anti-KIST/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的絲氨酸/蘇氨酸蛋白激酶KIST抗體(激酶相互作用與白血病相關基因)
別    名 kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; KIS; KIS protein kinase; KIST; Serine threonine protein kinase Kist; Serine/threonine-protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; UHMK1; UHMK1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  轉錄調節因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIST/UHMK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

Function:
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

Subunit:
Interacts with stathmin and CDKN1B/p27Kip1 (By similarity).

Subcellular Location:
Nucleus. Note=Mostly nuclear (By similarity).

Tissue Specificity:
Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
Contains 1 RRM (RNA recognition motif) domain.

Database links:
UniProtKB/Swiss-Prot: Q8TAS1.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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