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Rabbit Anti-Prostatic Acid Phosphatase/RBITC Conjugated antibody (bs-6293R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6293R-RBITC
英文名稱 Rabbit Anti-Prostatic Acid Phosphatase/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的前列腺酸性磷酸酶抗體
別    名 Acid phosphatase prostate; ACP 3; ACP3; ACPP; Ecto-5'-nucleotidase; PAP; PPAP_HUMAN; Prostatic acid phosphatase; Thiamine monophosphatase; TMPase; 5'-NT; 5'-nucleotidase.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  激酶和磷酸酶  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Prostatic Acid Phosphatase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Prostatic Acid Phosphatase is Belongs to the histidine acid phosphatase family.Cellular localization;Secreted and Lysosome membrane. Predominantly localized in the plasma membrane but also detected in intracellular vesicles.

Function:
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

Subunit:
Homodimer; dimer formation is required for phosphatase activity.

Subcellular Location:
Isoform 1: Secreted. Isoform 2: Cell membrane.
Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Tissue Specificity:
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells.

Post-translational modifications:
N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.

Similarity:
Belongs to the histidine acid phosphatase family.

Database links:

Entrez Gene: 504700 Cow

Entrez Gene: 55 Human

Entrez Gene: 56318 Mouse

Entrez Gene: 56780 Rat

Omim: 171790 Human

SwissProt: A6H730 Cow

SwissProt: P15309 Human

SwissProt: Q8CE08 Mouse

SwissProt: P20646 Rat

Unigene: 433060 Human

Unigene: 19941 Mouse

Unigene: 40121 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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