97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲一区二区三区777,欧美黄色tv,夜夜躁狠狠躁2021
Rabbit Anti-CREB-1/AP Conjugated antibody (bs-0035R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0035R-AP
英文名稱 Rabbit Anti-CREB-1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白抗體
別    名 Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB; CREB1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CREB-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.



Function:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Subunit:
Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.

DISEASE:
Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia (PubMed:22267179).

Similarity:
Belongs to the bZIP family.
Contains 1 bZIP domain.
Contains 1 KID (kinase-inducible) domain.

Database links:

Entrez Gene: 281713 Cow

Entrez Gene: 1385 Human

Entrez Gene: 12912 Mouse

Entrez Gene: 81646 Rat

Omim: 123810 Human

SwissProt: P27925 Cow

SwissProt: P16220 Human

SwissProt: Q01147 Mouse

SwissProt: P15337 Rat

Unigene: 516646 Human

Unigene: 453295 Mouse

Unigene: 90061 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白(cAMP responsive element binding protein, CREB)是真核細(xì)胞轉(zhuǎn)錄因子,屬于ATF/CREB家族。參與由cAMP或某些病毒蛋白質(zhì)所誘導(dǎo)基因轉(zhuǎn)錄的調(diào)節(jié)。
ATF/CREB家族相關(guān)蛋白
bs-0517R ATF-1 活化復(fù)制因子1
bs-0518R ATF-2 活化復(fù)制因子2
bs-0519R ATF-3 活化復(fù)制因子3
bs-0035M CREB 非磷酸化環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白(抗體)
bs-0036R P-CREB 磷酸化環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白(抗體)
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 永久免费不卡的AV网站 | 亚洲色成人WWW永久网站 | 國產精品倫一區二區三級視頻 | 国产极品美女高潮抽搐免费网站 | 成人在色线视频在线观看免费大全 | 亚洲AV无码国产在丝袜线观看 | 日韩成人精品一区二区三区 | 亚洲视频区 | 亚洲国产精品毛片AV不卡在线 | 91p在线观看| 最近免费中文字幕在线mv视频8 | 精品人妻无码一区二区三区丝袜 | 国产91xxx在线观看大全 | 日本免费在线看 | 久久久久久免费免费 | 久久国产亚洲精品 | 爆乳情帝国网综合社区 | 天天天操天天天干 | 欧美激情精品久久 | 久久久久久久福利 | 成人福利网址 | 性国产日韩欧美一区二区在线 | 啦啦啦资源视频在线完整免费高清 | 8x8ⅹ永久免费视频 精品无人码麻豆乱码1区2区 | 91精品国产色综合久久不卡蜜臀 | 99精品国产在热久久无毒不卡 | 影音先锋无码A∨男人资源站 | 亚洲精品国产福利 | 日韩一区二区三区四区在线 | 亚洲ΑV无码一区二区三区四区 | 无码AV波多野结衣久久 | 少妇又色又爽又高潮极品 | 国产精品老牛影院av | 欧美视频亚洲视频 | a一级黄色 | 强壮的公次次弄得我高潮a片日本 | 91久久人澡人人添人人爽欧美 | 欧美三级真做在线观看 | 中国丰满熟妇xxxx性 | 性国产牲交XXXXX视频 | 最新国产精品视频 |