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Rabbit Anti-MASH1/Gold Conjugated antibody (bs-1155R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-1155R-Gold
英文名稱 Rabbit Anti-MASH1/Gold Conjugated antibody
中文名稱 膠體金標記的神經母細胞特異性轉移因子抗體
別    名 Achaete scute complex homolog 1; ASCL1; MASH1/Achaete-scute homolog 1; Achaete scute complex homolog like 1; Achaete scute complex homologue 1; Achaete scute complex homologue like 1; Ascl 1; Ascl1; Ash 1; Ash1; Hash 1;Hash1; Mammalian achaete scute homolog 1; Mammalian achaete scute homologue 1; Mash 1; Mash1; Achaete-scute homolog 1; ASCL1_HUMAN; ASH-1; hASH1; Class A basic helix-loop-helix protein 46; bHLHa46.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 神經生物學  信號轉導  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Cow, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ASCL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Function:
Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.

Subcellular Location:
Nucleus (Probable).

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

Database links:

Entrez Gene: 429 Human

Entrez Gene: 17172 Mouse

Entrez Gene: 64186 Rat

Omim: 100790 Human

SwissProt: P50553 Human

SwissProt: Q02067 Mouse

SwissProt: P19359 Rat

Unigene: 703025 Human

Unigene: 136217 Mouse

Unigene: 32936 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ASCL1/ASH1是一種神經母細胞特異性轉移因子,可以促進細胞向一定方向分化但卻抑制了最終的分化環節,造成細胞停留于不成熟階段.
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