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Rabbit Anti-GADD45A/PE Conjugated antibody (bs-1360R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1360R-PE
英文名稱 Rabbit Anti-GADD45A/PE Conjugated antibody
中文名稱 PE標(biāo)記的生長抑制DNA損傷基因45抗體
別    名 Growth Arrest And DNA Damage Inducible Alpha; DNA Damage-Inducible Transcript 1 Protein; DDIT-1; GADD45; DDIT1; Growth Arrest And DNA Damage-Inducible Protein GADD45 Alpha; Growth Arrest And DNA-Damage-Inducible 45 Alpha; Growth Arrest And DNA-Damage-Inducible, Alpha; DNA Damage-Inducible Transcript-1; GA45A_HUMAN  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GADD45
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53 dependent and independent mechanisms.

Function:
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

Subunit:
Interacts with MAPK14. Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the GADD45 family.

Database links:

Entrez Gene: 1647 Human

Entrez Gene: 13197 Mouse

Entrez Gene: 25112 Rat

Omim: 126335 Human

SwissProt: P24522 Human

SwissProt: P48316 Mouse

SwissProt: P48317 Rat

Unigene: 80409 Human

Unigene: 72235 Mouse

Unigene: 10250 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GADD45α蛋白與細(xì)胞凋亡和死亡密切相關(guān),在某種程度上決定了細(xì)胞周期的進(jìn)程。
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