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Rabbit Anti-HPV18 E6 protein/AP Conjugated antibody (bs-0991R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0991R-AP
英文名稱 Rabbit Anti-HPV18 E6 protein/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的人類乳頭狀瘤病毒18 E6抗體
別    名 E6; Human Papilloma Virus; Human papillomavirus type 18 E6; Human papillomavirus type 18 (E6); Human papillomavirus type 18 E6; Human papillomavirus type 18 E6 protein; Protein E6; HPV18 E6 protein; VE6_HPV18.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 11kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Synthetic peptide from the HPV18 E6 protein conjugated to KLH
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.

Function:
Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.

Subunit:
Forms a complex with E6-AP ubiquitin-protein ligase which interacts with human P53. Binds to human FBLN1, MAGI3 and MPDZ.

Subcellular Location:
Host nucleus matrix (By similarity).

Similarity:
Belongs to the papillomaviridae E6 protein family.

Database links:
 Entrez Gene: 1489088 HPV18 E6

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

人類乳頭狀瘤病毒18(HPV18-E6)是導致女性宮頸癌的主要病毒型(包括人類乳頭狀瘤病毒16)
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