97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
色妹子影院,91看视频,爱情岛论坛成人av
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MAD1/PE-Cy5.5 Conjugated antibody (bs-1595R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1595R-PE-Cy5.5
英文名稱 Rabbit Anti-MAD1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的有絲分裂抑制缺陷蛋白1抗體
別    名 mitosis arrest deficiency 1; hMAD1; HsMAD1; MAD1L1; Mitotic arrest deficient 1; Mitotic checkpoint MAD1 protein homolog; Mitotic spindle assembly checkpoint protein MAD1; PIG9; Tax binding protein 181; TP53I9 ; Tumor protein p53 inducible protein 9; TXBP181; MD1L1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質和核信號  信號轉導  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MAD1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization.

Function:
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Subunit:
Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Interacts with NEK2. Interacts with TPR; the interactions occurs in a microtubule-independent manner.

Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Co-localizes with NEK2 at the kinetochore.

Tissue Specificity:
Expressed weakly at G0/G1 and highly at late S and G2/M phase.

Post-translational modifications:
Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage.

DISEASE:
Note=Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Similarity:
Belongs to the MAD1 family.

Database links:

Entrez Gene: 8379 Human

Omim: 602686 Human

SwissProt: Q9Y6D9 Human

Unigene: 654838 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 7788成人网站免费观看 | 日日碰狠狠丁香久燥 | 日韩中文字幕手机在线观看 | 亚洲第一天堂影院 | 久久不卡视频 | 动漫精品h | 中国一级黄色片 | 蜜桃av在线 | 一区二区三区日韩在线观看 | 超碰偷拍| 久久yy| 成人免费久久 | 97亚洲精华液 | 久久不卡视频 | 香港三级韩国三级日本三级 | 天天爽天天狠久久久综合麻豆 | 成全视频在线观看视频在线播放 | 国内91视频| 久久韩日 | 国产女合集小岁9三部 | 国产福利在线观看视频 | 四虎影视永久免费在线观看 | 18禁无遮挡免费视频网站 | 制服丝袜中文字幕无码自拍 | 日韩黄色大片在线观看 | 国产精品亚洲午夜不卡 | 狠狠狠的在啪线香蕉亚洲应用 | 国产狼人综合免费视频 | 三级黄色的视频 | 亚洲首页在线 | 浴室洗澡偷拍一区二区 | 亚洲自偷自偷图片 | 日韩中文字幕在线观看视频 | 国产aV永久精品无码 | 亚洲精品成人片在线播放4388 | 学生在线精品一区二区 | 国产激情视频网站 | 国产娱乐凹凸视觉盛宴在线视频 | 99视频在线无码 | 成人激烈床戏免费观看网站 | 国产成人精品午夜2022 |