97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
色妹子影院,91看视频,爱情岛论坛成人av
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-MAD1/PE-Cy5.5 Conjugated antibody (bs-1595R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1595R-PE-Cy5.5
英文名稱 Rabbit Anti-MAD1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的有絲分裂抑制缺陷蛋白1抗體
別    名 mitosis arrest deficiency 1; hMAD1; HsMAD1; MAD1L1; Mitotic arrest deficient 1; Mitotic checkpoint MAD1 protein homolog; Mitotic spindle assembly checkpoint protein MAD1; PIG9; Tax binding protein 181; TP53I9 ; Tumor protein p53 inducible protein 9; TXBP181; MD1L1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質和核信號  信號轉導  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MAD1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization.

Function:
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Subunit:
Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Interacts with NEK2. Interacts with TPR; the interactions occurs in a microtubule-independent manner.

Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Co-localizes with NEK2 at the kinetochore.

Tissue Specificity:
Expressed weakly at G0/G1 and highly at late S and G2/M phase.

Post-translational modifications:
Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage.

DISEASE:
Note=Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Similarity:
Belongs to the MAD1 family.

Database links:

Entrez Gene: 8379 Human

Omim: 602686 Human

SwissProt: Q9Y6D9 Human

Unigene: 654838 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 三级无码AV在线观看网址 | 粉嫩在线一区二区三区视频 | 无码成人精品区在线观看 | 一个人免费看的WWW在线观看 | 国产成人精品午夜福利 | 超碰在线观看免费 | 亚洲永久精品av在线观看 | 亚洲精品乱码久久久久膏 | 四虎国产精品永久在线国在线 | 四虎影视在线观看2413 | 国内精品久久久久影院免费 | 色yeye免费人成网站在线观看 | 师兄啊师兄在线 | 日本一区二区高清不卡 | 久久99久久精品国产 | 国产在线xxxx| 四虎影视永久免费在线观看 | 影音先锋无码AⅤ男人资源站 | 欧美成人A片无码免费 | 男人日女人逼的视频 | 久久久亚洲精品免费 | 亚洲第一免费视频 | 久久综合操 | 天天舔夜夜 | 国产永久伊人影院 | 裸体女人高潮毛片扒开一一区 | 无码人妻一区二区三区免费N鬼沢 | 亚洲一区av在线观看无码 | 99久久久国产精品免费蜜臀 | 大肉大捧一进一出好爽 | 国产成人AV片无码免费 | 午夜影院免费视频 | 孕妇奶水仑乱A级毛片免费看 | 国产精品偷伦在线观看 | 久久久亚洲精品一区二区三区 | 女女女女bbbb毛片免费视频 | 曰本人做爰大片免费观看 | 亚洲乱色熟女一区二区三区 | 日本亚洲国产黄www 香港三级日本三级韩国三级 | 一区二区三区四区乱码 | 国产亚洲女人久久久久毛片 |