97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩中文字幕av,免费黄色看片网站,国产一区二区三区www
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CRMP2/TOAD64/Cy3 Conjugated antibody (bs-1790R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1790R-Cy3
英文名稱 Rabbit Anti-CRMP2/TOAD64/Cy3 Conjugated antibody
中文名稱 Cy3標記的二氫嘧啶酶相關蛋白2抗體
別    名 Collapsin response mediator protein 2; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; CRMP-2; CRMP2; DHPRP 2; DHPRP2; Dihydr pyrimidinase 2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form; Dihydropyrimidinase related protein 2; Dihydropyrimidinase-related protein 2; DPYL 2; DPYL2; DPYL2_HUMAN; DPYSL 2; Dpysl2; DRP 2; DRP-2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; ULIP-2; Ulip2; Unc-33-like phosphoprotein 2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發育生物學  神經生物學  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRMP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Function:
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.

Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity). Interacts with CLN6.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.

Similarity:
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Database links:

Entrez Gene: 1808 Human

Entrez Gene: 12934 Mouse

Entrez Gene: 25416 Rat

Omim: 602463 Human

SwissProt: Q16555 Human

SwissProt: O08553 Mouse

SwissProt: P47942 Rat

Unigene: 173381 Human

Unigene: 352648 Mouse

Unigene: 475100 Mouse

Unigene: 2889 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CRMP2是一種腦特異性蛋白,對于軸突生長和軸突-樹突發育起到很重要的作用,CRMP2通過與微管蛋白二聚體結合并促進微管的組裝來調控軸突的生長和分支
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 色婷婷五月综合亚洲影院 | 国内自拍偷拍一区 | 亚洲尺码欧洲尺码有哪些品牌好 | a久久免费视频 | 久久久久久国产精品亚洲78 | 床震吃胸膜奶免费视频 | 国产真实乱对白精彩久久老熟妇女 | 精品国自产拍天天拍 | 日本正能量不良网站 | 人人爽人人爽人人爽人人片av | 高清亚洲 | 国产妇女乱码一区二区三区 | 久久精品人人爽人人爽 | 亚洲尺码欧洲尺码有哪些品牌好 | www.久草视频 | 久久久久久久久艹 | 欧美日韩视频免费观看 | 国产精品无 | 一级久久精品 | 日本一区二区三区视频中文字幕 | 黄色日本大片 | 久久伊人一区二区 | 一级做性色a爰片久久毛片免费 | 成人免费在线视频播放 | 超碰97在线免费 | 国产麻豆精品久久一二三 | 午夜影皖精品av在线播放 | AV人摸人人人澡人人超碰手机版 | 精品国产91久久久久久一区黄无 | 高清国产一区二区 | 人人草人人做人人爱 | 午夜影院 | 精品永久久福利一区二区 | 亚洲日本精品一区 | 国产精品久久久久7777婷婷 | 一区二区三区四区日韩 | 色视频一区| 亚洲一区二区三区免费观看 | 国产成人精品福利 | 欧美GAY猛男GAYA片18禁 | 黄色免看 |