97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
两个男人握着胸吃奶,日韩久久毛片,久久婷婷激情综合色综合俺也去
Rabbit Anti-CRMP2/TOAD64/BF594 Conjugated antibody (bs-1790R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1790R-BF594
英文名稱 Rabbit Anti-CRMP2/TOAD64/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的二氫嘧啶酶相關(guān)蛋白2抗體
別    名 Collapsin response mediator protein 2; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; CRMP-2; CRMP2; DHPRP 2; DHPRP2; Dihydr pyrimidinase 2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form; Dihydropyrimidinase related protein 2; Dihydropyrimidinase-related protein 2; DPYL 2; DPYL2; DPYL2_HUMAN; DPYSL 2; Dpysl2; DRP 2; DRP-2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; ULIP-2; Ulip2; Unc-33-like phosphoprotein 2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRMP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Function:
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.

Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity). Interacts with CLN6.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.

Similarity:
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Database links:

Entrez Gene: 1808 Human

Entrez Gene: 12934 Mouse

Entrez Gene: 25416 Rat

Omim: 602463 Human

SwissProt: Q16555 Human

SwissProt: O08553 Mouse

SwissProt: P47942 Rat

Unigene: 173381 Human

Unigene: 352648 Mouse

Unigene: 475100 Mouse

Unigene: 2889 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CRMP2是一種腦特異性蛋白,對于軸突生長和軸突-樹突發(fā)育起到很重要的作用,CRMP2通過與微管蛋白二聚體結(jié)合并促進(jìn)微管的組裝來調(diào)控軸突的生長和分支
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 人人草人 | 国产成人综合激情视频在线观看 | 少妇对白露脸打电话系列 | 超级碰碰人妻中文字幕 | 老司机精品视频一区二区 | 亚洲VS成人无码人在线观看堂 | 亚洲精品有限公司 | 一区二区三区AV波多野结衣 | 色综合一区 | 中文字幕亚洲色妞精品天堂 | 神马久久久久久久久久久 | 剑来在线观看 | 10000拍拍18勿入免费看动漫 | ww939766com永久免费 | 真人插b免费视频播放 | 国产成人精品综合久久久久99 | 91精品瑜伽老师夯老师网址 | 国内毛片久久 | 亚洲国产成人精品无码区在线网站 | 无码AV午夜福利一区 | 最近更新中文字幕手机版 | 欧美日韩一区二区三区不卡 | 狠狠操一区二区三区 | yy111111少妇影院免费 | 在线播放毛片 | 成人av在线网 | 激情av无码后入 | www国产| 四虎国产精品成人 | 久久精品aaa| 成人做爰69片免费 | 无码AV免费一区二区三区四区 | 日韩国产精品91 | 啦啦啦资源视频在线完整免费高清 | 99999色 | 日本伊人精品一区二区三区观看方式 | 中文av一区| 亚洲色大成网站久久久 | 91精品国产福利 | 久久久亚洲精品免费 | 99re视频在线观看 |