97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美牲交a免费,乱人伦在线视频,麻豆精品导航
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-PAK3 (Ser139)/Cy5.5 Conjugated antibody (bs-1655R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1655R-Cy5.5
英文名稱 Rabbit Anti-phospho-PAK3 (Ser139)/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的磷酸化p21激活激酶3抗體
別    名 PAK3_HUMAN; Beta PAK; bPAK; CDKN1A; hPAK3; Mental retardation X linked 30; MRX30; MRX47; Oligophrenin 3; OPHN3; p21 activated kinase 3; p21 CDKN1A activated kinase 3; PAK-3; PAK3 p21 protein (Cdc42/Rac)-activated kinase 3; PAK3beta; Pak65alpha; Pak65beta; Serine threonine protein kinase PAK 3; Stk4.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 細胞生物  神經生物學  信號轉導  激酶和磷酸酶  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 62kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PAK3 around the phosphorylation site of (Ser139)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.

Function:
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments.

Subunit:
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. Interacts with the C-terminal of APP (By similarity). Interacts with ARHGEF6 and ARHGEF7.

Subcellular Location:
Cytoplasm (By similarity).

Tissue Specificity:
Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.

Post-translational modifications:
Autophosphorylated when activated by CDC42/p21.

DISEASE:
Mental retardation, X-linked 30 (MRX30) [MIM:300558]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CRIB domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5058 Human

Entrez Gene: 18479 Mouse

Entrez Gene: 29431 Rat

Omim: 602590 Human

SwissProt: Q13153 Human

SwissProt: O88643 Mouse

SwissProt: P35465 Rat

Unigene: 435714 Human

Unigene: 260227 Mouse

Unigene: 9149 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PAK1-3蛋白具有廣泛的生物學功能,也是一個保守的絲氨酸/蘇氨酸蛋白激酶,參與許多重要的細胞活動。包括細胞骨架的動力學調節,細胞移動,生存和凋亡,細胞周期,基因轉錄調節,細胞生長信號轉導和轉化等。
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 一级黄a视频 | 全免费午夜一级毛片真人 | av大片免费看 | 国产精品三级在线观看 | 欧美亚洲另类在线观看 | 国产最顶级的黄色片在线免费观看 | 久热精品在线观看 | 日本无人区码suv | 亚洲欧美日韩专区 | 国产SUV精品一区二区33 | gogo大胆无码免费视频列表 | a中文在线视频 | 日本国产黄色 | 日韩精品无码久久一区二区三 | 超碰网站在线 | 日本少妇高潮正在线播放 | 亚洲国产青草 | 欧美在线观看视频 | 国产精品人妻熟女a8198v久 | 无码免费一区二区三区免费播放 | 国语国产精精品国产国语清晰对话 | 超碰中文字幕在线 | 日韩亚洲欧美在线 | 精品久久久久久18免费网站 | 久久久女人视频 | 96超碰在线 | 8天堂资源在线 | 欧美Ⅴ永久无码精品毛片 | 亚洲精品久久久中文字幕 | 91麻精品国产91久久久久 | 国语国产精精品国产国语清晰对话 | 久草视频精品 | 亚洲第一页在线视频 | 亚洲精品无码永久在线观看性色 | 久国久产久精永久网页 | 91成人免费版 | 日本一区二区三区视频中文字幕 | 国产一区影院 | 同性男一级毛片 | 狠狠色婷婷久久一区二区三区91 | 97久久夜色精品国产九色 |