97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
99精产国品一二三产区区免费,三级网站在线观看视频,日本激情网址
Rabbit Anti-CAMK2A + CAMK2B + CAMK2D/FITC Conjugated antibody (bs-0541R-FITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0541R-FITC
英文名稱 Rabbit Anti-CAMK2A + CAMK2B + CAMK2D/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的鈣/鈣調(diào)素依賴蛋白激酶2b/2γ抗體
別    名 CaMK2 beta+gamma+delta; CaMK2 beta; CaMK2 gamma; CaMK2 delta; CAMK2G; Calcium/calmodulin dependent protein kinase (CaM kinase) II beta; Calcium/calmodulin dependent protein kinase II beta; Calcium/calmodulin dependent protein kinase IIB; Calcium/calmodulin dependent protein kinase type II beta chain; CAM 2; CaM kinase II beta chain; CaM kinase II beta subunit; CAM2; CAMK 2; CAMK 2B; CaMK II beta subunit; CaMK II subunit beta; CAMK2; CaMK2 beta; CAMK2B; CAMKB; CaMKII beta subunit; CaMKIIB; MGC29528; Proline rich calmodulin dependent protein kinase; CaM kinase II; Calcium/calmodulin-dependent protein; CaM kinase II gamma subunit; CaM-kinase II gamma chain; CaM kinase II delta subunit; CaM-kinase II delta chain; CAM2; CAMK; CAMK-II; CAMK2D; CAMK2G; CAMK2N2; CAMKD; CAMKG; KCC2B; kinase CaMK2-beta.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53-73kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CaMK2 beta/ gamma/ delta
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Subunit:
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Tissue Specificity:
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Post-translational modifications:
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 815 Human

Entrez Gene: 816 Human

Entrez Gene: 817 Human

Entrez Gene: 108058 Mouse

Entrez Gene: 12322 Mouse

Entrez Gene: 12323 Mouse

Entrez Gene: 24245 Rat

Entrez Gene: 24246 Rat

Entrez Gene: 25400 Rat

Omim: 114078 Human

Omim: 607707 Human

Omim: 607708 Human

SwissProt: Q13554 Human

SwissProt: Q13557 Human

SwissProt: Q9UQM7 Human

SwissProt: P11798 Mouse

SwissProt: P28652 Mouse

SwissProt: Q6PHZ2 Mouse

SwissProt: P08413 Rat

SwissProt: P11275 Rat

SwissProt: P15791 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CaMK2b也是絲/蘇氨基酸激酶的一種,同屬于Ca++/鈣調(diào)素依賴性蛋白質(zhì)激酶家族成員。鈣/鈣調(diào)素依賴性蛋白激酶Ⅱb(CaMKⅡb)廣泛分布于中樞神經(jīng)系統(tǒng)內(nèi),參與調(diào)節(jié)神經(jīng)遞質(zhì)的合成釋放、信號(hào)轉(zhuǎn)導(dǎo)和突觸可塑性的形成以及磷酸化蛋白
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 日韩一级成人av | 国产成人AV大片在线播放 | 在线观看91精品国产入口 | 日韩中文字幕免费观看 | 日本成人综合 | 篱笆女人狗电视连续剧第一部 | 一区二区三区四区视频免费观看 | 毛片久久久久 | 国产香蕉青春草原久久 | 亚洲成人免费视频在线 | 日韩高清在线观看 | 日韩一区二区三区高清免费看看 | 日韩一区二区观看 | 内射巨臀欧美在线视频 | 夜夜爽8888免费视频 | 亚洲国产精品久久久久久69 | 免费无码中文字幕A级毛片 中文字幕一区二区在线视频 | 91精品国产色综合久久不卡蜜臀 | 免费观看的av网站 | 天天摸日日添狠狠添婷婷 | 理伦三级 | 一级黄色片免费看 | 不卡av中文字幕手机看 | 篱笆女人狗电视连续剧第一部 | 无人高清视频免费观看在线 | 久久精品亚洲男人的天堂 | 欧美一区=区三区 | 骚老师av在线 | 无码精品A∨在线观看中文 国产午夜精品片一区二区三区 | 亚洲综合色视频 | 78午夜福利视频 | 少妇愉情理伦片高潮日本 | 肉岳疯狂69式激情的高潮 | 久久99精品久久久噜噜最新章节 | 人人鲁免费播放视频 | 亚洲人成影视在线观看 | 色一欲一性一乱一区二区三区 | 午夜视频福利网站 | 国产精品高潮久久 | 色AV综合AV综合无码网站 | 四虎影视最新网站 |