97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
自拍偷拍视频二区,久久天堂综合亚洲伊人hd妓女,六月天综合网
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CO4A2/AP Conjugated antibody (bs-7501R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7501R-AP
英文名稱 Rabbit Anti-CO4A2/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的膠原蛋白4a2亞基抗體
別    名 Collagen alpha 2(IV) chain; Canstatin; COL4A 2; COL4A2; Collagen, type IV, alpha 2; CO4A2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  信號轉導  細胞骨架  細胞外基質  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25/149kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Collagen alpha-2(IV) chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
CO4A2 is one of the six subunits of type IV collagen, the major structural component of basement membranes. CO4A2 fors a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen and is an inhibitor of angiogenesis and tumor growth.

Function:
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Subunit:
There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.

Post-translational modifications:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. [PTM] The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues (By similarity).
Proteolytic processing produces the C-terminal NC1 peptide, canstatin.

DISEASE:
Defects in COL4A2 are the cause of porencephaly type 2 (POREN2) [MIM:614483]. POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. [DISEASE] Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH) [MIM:614519]. ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Similarity:
Belongs to the type IV collagen family.
Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.

Database links:
UniProtKB/Swiss-Prot: P08572.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 在线观看a视频 | 久久频这里精品99香蕉 | 中文字字幕在线乱码 | 日韩色综合 | 亚洲欧美日韩精品成人 | 宅男一区 | 欧洲美女粗暴牲交视频免费 | 色偷偷色噜噜狠狠网站久久 | 在线三级av | 成人做爰69片免网站 | 青青操在线播放 | 国产伦精品免费视频 | 35岁少妇被23岁小伙征服 | 欧美激情网页 | 在线不卡视频 | 国产成人一区二 | av在线亚洲天堂 | 久久国产精品成人无码网站 | 国产亚洲精品麻豆一区二区 | 欧美亚洲中日韩中文字幕在线 | 国产一区二区三区四区成男人 | 国产精品久久久亚洲 | 欧美亚洲欧美 | 亚洲人成网站在线观看妞妞网 | 91一区| 夜夜爱天天干 | 91黄色免费看 | 免费A级毛片无码A∨性按摩 | 欧美亚洲另类在线观看 | 久久国产精品久久久 | 国产精品动漫一区二区 | 免费AV网在线观看 | 中文字幕在线一区二区三区 | 欧美一级免费高清 | 乱人伦人妻中文字幕无码久久网 | 老人内射视频代码免费视频 | 久久精品国产99精品最新 | 午夜理理伦A级毛片天天看 一区视频免费观看 | 久久精品一二 | 国产精品线在线精品 | 国产亚洲精品久久久999密壂 |