97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲精品免费观看,久9久热,欧美三区二区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-EphA7/AP Conjugated antibody (bs-7034R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7034R-AP
英文名稱 Rabbit Anti-EphA7/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的酪氨酸蛋白激酶受體A7抗體
別    名 Cek 11; Developmental kinase 1; EBK; EHK-3; EHK3; EK11; Embryonic brain kinase; Eph homology kinase 3; Eph receptor A7; EPH-like kinase 11; EphA7; EPHA7_HUMAN; Ephrin receptor Eph A7; Ephrin type A receptor 7; Ephrin type-A receptor 7; hEK11; MDK 1; Receptor protein tyrosine kinase HEK 11; Tyrosine protein kinase receptor EHK 3.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  免疫學  神經生物學  信號轉導  激酶和磷酸酶  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Horse, Rabbit, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50/107kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EphA7 (200-250aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Receptor for members of the ephrin-A family. Binds to ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4 and ephrin-A5.

Function:
’Receptor tyrosine kinase which binds promiscuouslyGPI-anchored ephrin-A family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling intoneighboring cells. The signaling pathway downstream of the receptoris referred to as forward signaling while the signaling pathwaydownstream of the ephrin ligand is referred to as reversesignaling. Among GPI-anchored ephrin-A ligands, EFNA5 is acognate/functional ligand for EPHA7 and their interaction regulatesbrain development modulating cell-cell adhesion and repulsion. Hasa repellent activity on axons and is for instance involved in theguidance of corticothalamic axons and in the proper topographicmapping of retinal axons to the colliculus. May also regulate braindevelopment through a caspase(CASP3)-dependent proapoptoticactivity. Forward signaling may result in activation of componentsof the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 ANDMAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4which lacks the kinase domain may regulate isoform 1 adhesiveproperties.

Subunit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain).

Subcellular Location:
Cell membrane (Probable); Single-pass type I membrane protein (Probable).

Tissue Specificity:
Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen.

Post-translational modifications:
Phosphorylated. Isoform 4 inhibits isoform 1 phosphorylationand may regulate its function in adhesion.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 2045 Human

Entrez Gene: 13841 Mouse

Entrez Gene: 171287 Rat

Omim: 602190 Human

SwissProt: Q15375 Human

SwissProt: Q61772 Mouse

SwissProt: P54759 Rat

Unigene: 73962 Human

Unigene: 257266 Mouse

Unigene: 10181 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 99久e精品热线免费 狠狠躁夜夜a产精品视频 | 红杏出墙在线 | 91国在线高清视频 | 亚洲激情四射视频中文字幕久久 | 天操夜夜操| 亚洲精品视频大全 | 无码专区无码专区视频网址 | 国语少妇高潮对白在线 | 天天做天天爱天天综合网2021 | 日韩在线播放网站 | 色黄啪啪网18以下勿进 | 国产一级大毛片 | 97成人资源网 | 亚洲国产精品va在线看黑人动漫 | 午夜福利无码不卡在线观看 | 一本久道综合在线中文无码 | 国产成人一区二 | 亚洲高清揄拍自拍AV | 在线看av网址 | 99精品国产在热久久无毒不卡 | 老司机免费在线视频 | 久久九色| 日韩精品欧美在线成人 | a级毛片高清免费视频就 | a级黄色 | 精品少妇XXXX | 亚洲小视频网站 | 波多野结衣视频在线 | 91在线免费看 | 最新看片国产精品免费在线 | 久精品久久 | 97久久超碰成人精品网站 | 久久精品国产成人精品 | 东北农村女人乱淫免费视频 | 在线中文免费视频 | 国产免费一级特黄真人视频 | 亚洲欧美视频播放 | 中文人妻无码一区二区三区 | 日韩在线一二三 | 日本久久综合 | 在线视频1区 |