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Rabbit Anti-IGFBP4/AP Conjugated antibody (bs-1823R-AP)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1823R-AP
英文名稱 Rabbit Anti-IGFBP4/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的胰島素樣生長(zhǎng)因子結(jié)合蛋白4抗體
別    名 Insulin-like Growth Factor Binding Protein 4; BP 4; BP4; HT29 IGFBP; IBP 4; IBP4; IGF binding protein 4; IGFBP 4; IBP4_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  糖尿病  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IGFBP4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulin like growth factor binding protein 4 (IGFBP4) is produced from a DNA sequence encoding the human IGFBP4 protein. Mature human IGFBP4 has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, the recombinant protein migrates as a 32 kDa and 25 kDa protein under reducing and non reducing conditions, respectively. Human IGFBP4 has a potential N-linked glycosylation site and shares approximately 90% amino acid sequence identity with both mouse and rat IGFBP4. IGFBP4 is a member of the superfamily of insulin-like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). IGFBP4 functions as an inhibitor of IGF action and its main function may be to protect cells from overstimulation by IGFs or to allow activation of alternate transmembrane signaling pathways that are inhibited by IGF exposure. IGFBP4 is expressed in multiple tissues including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex.

Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subunit:
Binds IGF2 more than IGF1.

Subcellular Location:
Secreted.

Similarity:
Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.

Database links:

Entrez Gene: 374271 Chicken

Entrez Gene: 282262 Cow

Entrez Gene: 3487 Human

Entrez Gene: 16010 Mouse

Entrez Gene: 360622 Rat

Entrez Gene: 443470 Sheep

Omim: 146733 Human

SwissProt: Q05716 Cow

SwissProt: P22692 Human

SwissProt: P47879 Mouse

SwissProt: P24854 Pig

SwissProt: P21744 Rat

SwissProt: Q28893 Sheep

Unigene: 462998 Human

Unigene: 233799 Mouse

Unigene: 160666 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長(zhǎng)因子和激素( Growth Factor and Hormones)
IGFBP5胰島素樣生長(zhǎng)因子結(jié)合蛋白4(IGFBP-4)是一種可以與胰島素樣生長(zhǎng)因子(IGFs)結(jié)合的分泌性蛋白,其通過(guò)IGFs調(diào)節(jié)細(xì)胞的生長(zhǎng)、分化、凋亡、黏附和運(yùn)動(dòng),IGFBP-4與IGFs結(jié)合可以調(diào)節(jié)IGFs與IGF-I型受體間的相互作用,改變其促有絲分裂效應(yīng)、凋亡抑制效應(yīng)和促細(xì)胞運(yùn)動(dòng)作用.
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