97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中国农村熟妇性视频,久久国产色av,国产高清视频色拍
Rabbit Anti-LEF-1/Gold Conjugated antibody (bs-1843R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1843R-Gold
英文名稱 Rabbit Anti-LEF-1/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的淋巴增強(qiáng)因子-1抗體
別    名 lymphoid enhancing factor-1; Transcription factor T cell specific 1 alpha ; DKFZp586H0919; LEF 1; LEF1; Lymphoid enhancer binding factor 1; T cell specific transcription factor 1 alpha; TCF 1 alpha; TCF1 alpha; TCF1alpha; TCF1-alpha; LEF1_HUMAN; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LEF-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

Function:
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Subunit:
Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.

Subcellular Location:
Nucleus. Note=Found in nuclear bodies upon PIASG binding.

Tissue Specificity:
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.

Post-translational modifications:
Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.

Similarity:
Belongs to the TCF/LEF family.
Contains 1 HMG box DNA-binding domain.

Database links:

Entrez Gene: 51176 Human

Omim: 153245 Human

SwissProt: Q9UJU2 Human

Unigene: 726506 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

lef-1是淋巴增強(qiáng)因子/T-細(xì)胞因子(LEF/TCF)家族的成員之一,屬于高遷移率組分蛋白家族。lef-1也是一個(gè)重要的轉(zhuǎn)錄因子,是Wnt信號(hào)通路的核心成分。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 老司机福利在线视频 | 麻豆疯狂做受xxxx高潮视频 | 免费人成在线观看成人片 | 色AV综合AV综合无码网站 | 久久免费黄色网址 | 国产精品二区三区在线观看 | 日韩a级作爱片一二三区免费观看 | av网址免费在线观看 | 亚一区二区| 亚洲欭美日韩颜射在线二 | 亚洲ΑV无码一区二区三区四区 | 在线亚洲无砖砖区免费 | 2222www色视频在线观看 | 国产成人啪精品视频免费网站 | 国产精品无码一区二区三区无卡 | 国语国产精精品国产国语清晰对话 | 国产女同2互磨高潮在线观看 | 中文字幕欧美日韩一区 | 黄色视网站 | 亚洲国产精品一区二区第一页 | 在线观看免费视频国产 | 我要看免费的黄色片 | 久久婷婷成人综合色综合 | 超碰偷拍 | 精品欧美不卡一区二区在线观看 | 17草视频 | 国产高清在线视频观看 | av一区在线观看 | 免费黄在线观看 | 小老弟av影院 | 亚洲精品久久久一区二区图片 | 国产成人福利视频 | 亚洲国产精品乱码一区二区三区 | 婷婷六月激情 | 精品国产乱码一区二区三区 | 男人肌肌捅女人肌肌视频 | 69久久夜色精品国产69蝌蚪网 | 亚洲精品在线视频免费观看 | 中文av字幕在线观看 | 99久久国产综合精品女不卡 | 国产色爽女 |