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Rabbit Anti-alpha MSH/Gold Conjugated antibody (bs-1848R-Gold)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-1848R-Gold
英文名稱 Rabbit Anti-alpha MSH/Gold Conjugated antibody
中文名稱 膠體金標記的促黑細胞激素α抗體
別    名 MSH Alpha; alpha melanocyte stimulating hormone; Alpha MSH; Melanotropin alpha; POMC; proopiomelanocortin;Alpha-MSH; Melanotropin alpha; proopiomelanocortin; COLI_HUMAN.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 1.4kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide of human Alpha-MSH
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Function:
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases thepigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Location:
Secreted.

Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.

Similarity:
Belongs to the POMC family.

Database links:

Entrez Gene: 5443 Human

Entrez Gene: 18976 Mouse

Entrez Gene: 24664 Rat

Omim: 176830 Human

SwissProt: P01189 Human

SwissProt: P01193 Mouse

SwissProt: P01194 Rat

Unigene: 1897 Human

Unigene: 277996 Mouse

Unigene: 108195 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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