97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
夜夜爽天天干,亚洲三级成人,亚欧综合在线
Rabbit Anti-MCM2/AP Conjugated antibody (bs-1981R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1981R-AP
英文名稱 Rabbit Anti-MCM2/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的微小染色體維持缺陷蛋白2抗體
別    名 BM28; CCNL 1; CCNL1; CDC like 1; CDC like-1; cdc19; CDCL 1; CDCL1; Cell devision cycle like 1; Cyclin like 1; cyclin like-1; D3S3194; DNA replication licensing factor MCM2; KIAA0030; MCM 2; MCM2; MCM2 minichromosome maintenance deficient 2 mitotin; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae); MCM2 minichromosome maintenance deficient 2, mitotin; MCM2_HUMAN; MCM2_MOUSE; MGC10606; Minichromosome maintenance complex component 2; Minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance deficient 2 mitotin; Minichromosome maintenance protein 2; Minichromosome maintenance protein 2 homolog; Mitotin; Nuclear protein BM28; OTTHUMP00000216047; OTTHUMP00000216050.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號(hào)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse MCM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

Function:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Subunit:
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Interacts with KAT7 and DBF4. May interact with MCM10.

Subcellular Location:
Nucleus (Probable).

Post-translational modifications:
Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication.

Similarity:
Belongs to the MCM family.
Contains 1 MCM domain.

Database links:

Entrez Gene: 4171 Human

Entrez Gene: 17216 Mouse

Entrez Gene: 312538 Rat

Omim: 116945 Human

SwissProt: P49736 Human

SwissProt: P97310 Mouse

Unigene: 477481 Human

Unigene: 16711 Mouse

Unigene: 2715 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

微小染色體維持缺陷蛋白2又稱微型染色體維持蛋白2或絲裂蛋白,MCM-2是細(xì)胞周期階段的特異性標(biāo)志物,在進(jìn)入細(xì)胞周期的細(xì)胞中均有表達(dá),在細(xì)胞的增值、分化中起到一定的作用。
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 色噜噜一区二区三区 | 35日本xxxxxxxxx25| 中国少妇内射XXXXⅩ | 亚洲国产精品一区二区久 | 办公室扒开奶罩揉吮奶头AV | 久久国产精品成人无码网站 | 亚洲韩国欧洲国产日产av | 日韩亚洲欧美在线 | 特级黄色片免费看 | aaa日本高清在线播放免费观看 | 欧美日韩一区二区精品 | 麻豆视频一区二区三区 | 国产AV综合影院 | 一本一道久久a久久综合蜜桃 | 日本一区视频在线观看 | 国产在线观看第一页 | 久久99免费视频 | 国产一卡二卡三卡四卡 | 国产一区二区在线在线 | 国产一二区不卡 | 校园春色另类小说 | 污污网站国产精品白丝袜 | oidgrαnny日本老熟妇 | 天天躁日日躁aaaa视频 | 最新国产精品视频 | 秀人网妲己xiurenwang.cc | 国产成人综合亚洲AV第一页 | 欧美老人巨大xxxx做受视频 | 亚洲精品一区二区成人 | 18勿看免费大片1000拍拍 | 不戴奶罩的教师水卜樱在线观看 | 亚洲人午夜精品免费 | 久久中文字幕一区二区三区 | 成人福利网址 | 免费高清一区二区三区 | 波多野结衣中文字幕免费观看 | 玩麻豆国产?片对白日逼视频 | 成人午夜福利视频网址 | 91欧美亚洲 | 91精品综合久久久久久3u8 | 国产网红主播精品一区二区三区 |