97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
中国三级在线,国产精品久久久久aaaa,runaway韩剧动漫
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-KCNJ5/BF594 Conjugated antibody (bs-9931R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9931R-BF594
英文名稱 Rabbit Anti-KCNJ5/BF594 Conjugated antibody
中文名稱 BF594標記的G蛋白激活內向鉀通道5抗體
別    名 inwardly rectifying subfamily J member 5; Cardiac ATP sensitive potassium channel; Cardiac inward rectifier; CIR; G protein activated inward rectifier potassium channel 4; G protein-activated inward rectifier potassium channel 4; GIRK 4; GIRK-4; GIRK4; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; Inward rectifier K+ channel KIR3.4; IRK-4; IRK5_HUMAN; KATP 1; KATP-1; KATP1; KCNJ 5; Kcnj5; KIR 3.4; KIR3.4; Potassium channel; Potassium channel inwardly rectifying subfamily J member 5; Potassium inwardly rectifying channel J5; Potassium inwardly rectifying channel subfamily J member 5.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  神經生物學  通道蛋白  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNJ5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008].

Function:
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Subunit:
May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Islets, exocrine pancreas and heart.

DISEASE:
Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13) [MIM:613485]. It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
Defects in KCNJ5 are the cause of familial hyperaldosteronism type 3 (FH3) [MIM:613677]. A form of hyperaldosteronism characterized by hypertension secondary to massive adrenal mineralocorticoid production. Like patients with familial hyperaldosteronism type 1 (glucocorticoid-remediable aldosteronism), patients with FH3 present with childhood hypertension, elevated aldosteronism levels, and high levels of the hybrid steroids 18-oxocortisol and 18-hydroxycortisol. However, hypertension and aldosteronism are not reversed by administration of exogenous glucocorticoids and patients require adrenalectomy to control hypertension.
Note=Somatic mutations in KCNJ5 have been found in aldosterone-producing adrenal adenomas and can be responsible for aldosteronism associated with cell autonomous proliferation. These are typically solitary, well circumscribed tumors diagnosed between ages 30 and 70. They come to medical attention due to new or worsening hypertension, often with hypokalemia. KCNJ5 mutations produce increased sodium conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium entry, the signal for aldosterone production and cell proliferation.

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.

Database links:

Entrez Gene: 3762 Human

Entrez Gene: 16521 Mouse

Entrez Gene: 29713 Rat

Omim: 600734 Human

SwissProt: P48544 Human

SwissProt: P48545 Mouse

SwissProt: P48548 Rat

Unigene: 632109 Human

Unigene: 69472 Mouse

Unigene: 10047 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Involvement in disease; Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13). It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: www.91在线观看 | 又大又粗又爽免费视频a片 婷婷五月综合丁香在线 | 久草在线在线精品观看 | 精品久久伊人99热超碰 | 亚洲视频二区在线观看 | 超碰在线日本 | 欧美拍拍视频免费大全 | 国产95亚洲 | 免费观看很黄很色裸乳视频网站 | 男女视频免费看 | 亚洲午夜精品久久久久久高潮 | 日韩欧美亚洲国产精品字幕久久久 | 人妻三级日本三级日本三级极 | 日韩精品在线免费视频 | 亚洲国产成人精品无码一区二区 | 好爽好大久久久级淫片毛片小说 | 91精品一区二区三区在线观看 | 国产精品无码专区网站 | 亚洲精品久久久久久中文传媒 | 国产人妻精品区一区二区 | 欧美黑人粗暴多交高潮水最多 | 中国视频一区二区 | 无码H肉3D动漫在线观看 | 狠狠色综合欧美激情 | 年轻富婆私密推油到高潮 | 999www人成免费视频 | www.久久 | 国产精品无码无卡无需播放器 | 最新视频-x88av| 成网在线看 | 亚洲理论中文字幕 | 国产精品高潮久久 | 我真的不是气运之子动漫免费观看 | 欧美一区1区三区3区公司 | 高清一区二区中文字幕 | 色两性网欧美 | 91在线观看网站 | 男男做爰猛烈高潮在线观看 | www中文在线 | 亚洲高清免费观看在线视频 | 92精品国产自产在线观看481页 |