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Rabbit Anti-DLK1/FITC Conjugated antibody (bs-2423R-FITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2423R-FITC
英文名稱 Rabbit Anti-DLK1/FITC Conjugated antibody
中文名稱 FITC標記的穿膜蛋白DLK1抗體
別    名 Adipocyte differentiation inhibitor protein; Brevideltin; Delta like 1 homolog; Delta like homolog; Delta like protein; Delta1; DLK 1; DLK; DLK-1; Dlk1; DLK1_HUMAN; FA 1; FA1; Fetal antigen 1; pG2; Preadipocyte factor 1; Pref 1; Pref; Pref1; Pref-1; Protein delta homolog 1; Secredeltin; ZOG; Delta1; PREF1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  神經生物學  信號轉導  干細胞  轉錄調節因子  結合蛋白  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Pig, Rabbit, Sheep, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DLK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010].

Function:
May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.

Subunit:
Monomer.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 6 EGF-like domains.

Database links:

Entrez Gene: 8788 Human

Entrez Gene: 13386 Mouse

Entrez Gene: 114587 Rat

Omim: 176290 Human

SwissProt: P80370 Human

SwissProt: Q09163 Mouse

Unigene: 533717 Human

Unigene: 157069 Mouse

Unigene: 14547 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

穿膜蛋白DLK1又稱肝癌相關基因,是表皮生長因子(EGF)家族的成員之一,其結構特征為蛋白的細胞外區域擁有在結構及氨基酸序列上與表皮生長因子高度同源的重復結構.DLK1可以抑制脂肪前體細胞向脂肪細胞分化,在正常神經內分泌細胞及其腫瘤細胞中表達, DLK1在神經內分泌軸中起著調控細胞生長分化的作用,同時DLK1在胚胎肝、造血干細胞及早期肌肉組織中均有表達。
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