97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
最近日韩中文字幕,日日干影院,久久国产免费
Rabbit Anti-ENAH/PE-Cy3 Conjugated antibody (bs-9660R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9660R-PE-Cy3
英文名稱 Rabbit Anti-ENAH/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的ENAH蛋白抗體
別    名 ENA; Enah; ENAH_HUMAN; MENA; NDPP1; Protein enabled homolog.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ENAH/MENA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
EVL is an Actin-binding protein that belongs to the Mena/VASP protein family. EVL is expressed in filopodial tips and localizes to the edge of the lamellipodia and focal adhesions. In epithelial cells, EVL localizes to the membrane of the lateral domain. EVL contains an N-terminal EVH1 domain, a proline-rich core and a C-terminal EVH2 domain. Via its proline-rich domain, EVL interacts with the SH3 domain of spectrin a II and the LIM domain of TES. EVL is closely related to VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein). Mena is highly expressed in the developing nervous system and may be involved in growth cone motility and axon guidance; VASP is involved in the maintenance of cyto-architecture by interacting with Actin-like filaments. All three proteins, EVL, Mena and VASP, are involved in cell motility and the regulation of cytoskeletal organization and dynamics.

Function:
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. Required for the actin-based mobility of Listeria monocytogenes.

Subunit:
Homotetramer. Interacts with APBB1IP, APBB1, PFN1 and ROBO4. Isoforms, containing the polyproline-rich regions with PPLP motifs, bind the WW domain of APBB1IP. Isoforms, containing the PPSY motif, bind, in vitro, to the WW2 and WW3 domains of NEDD4 and to the WW1 domain of YAP1. Binds the SH3 domain of BAIAP2-alpha but only after the autoinhibitory region of BAIAP2-alpha has been blocked by interaction with CDC42. Interacts, via the EVH1/WH1 domain, with the Pro-rich domains from VCL, ZYX and Listeria monocytogenes actA and with TES (via LIM domains). The TES LIM domain and the Pro-rich domains from VCL or ZYX compete for the same binding site. Interaction with ZYX is important for targeting ENAH to focal adhesions and enhances production of actin-rich structures at the apical surface of cells. Interacts, through the Pro-rich region, with the C-terminal SH3 domain of DNMPB. Binds GPHN. Interacts with FAT1 (via EVH1 domains). Heterotrimer with TES and ACTL7A.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, filopodium. Cell junction, synapse. Cell junction, focal adhesion. Note=Targeted to the leading edge of lamellipodia and filopodia by MRL family members. Colocalizes at filopodial tips with a number of other proteins including vinculin and zyxlin. Colocalizes with N-WASP at the leading edge. Colocalizes with GPHN and PFN at synapses.

Tissue Specificity:
Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions.

Post-translational modifications:
NTN1-induced PKA phosphorylation on Ser-265 directly parallels the formation of filopodial protrusions.
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the Ena/VASP family.
Contains 1 WH1 domain.

Database links:

Entrez Gene: 55740 Human

Entrez Gene: 13800 Mouse

Entrez Gene: 360891 Rat

Omim: 609061 Human

SwissProt: Q8N8S7 Human

SwissProt: Q03173 Mouse

Unigene: 497893 Human

Unigene: 389224 Mouse

Unigene: 87759 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 红杏出墙在线 | 欧美jizzhd精品欧美 | 99热在线成人 | 日韩久久无码免费看A | 老司机带带我免费视频 | 色婷婷五月综合激情中文字幕 | 国产精品在线看 | 99国内精品久久久久久久 | 91九色论坛 | 亚洲日韩国产AV无码无码精品 | 正在做饭的少妇中文字幕 | 一区二区三区精品视频免费看 | xxxx另类黑人 | 色呦呦官网 | 狠狠做深爱婷婷久久综合一区 | 999www人成免费视频 | 精品国产日韩亚洲一区 | 亚洲中文字幕无码久久2017 | 夜夜爽夜夜叫夜夜高潮 | 色噜噜一区二区三区 | 欧美xxxxx18 | 00粉嫩高中生洗澡偷拍视频 | 国产成熟人妻换╳╳╳╳ | 中文字幕无码肉感爆乳在线 | 亚洲熟女AV综合网五月 | 亚洲小视频网站 | 狠狠综合久久久久综合 | 国内精品久久久久精品 | 久久久国产午夜精品 | 国产成人精品国内自产拍免费看 | 一区二区免费在线观看视频 | 免费AV网在线观看 | 林雅诗三级无删减在线观看 | 中文字幕视频免费观看 | 国产精品美女久久久久久不卡 | 特级a欧美做爰片毛片 | 无码人妻精品中文字幕 | 亚洲欧美综合国产不卡 | 日韩精品美腿丝袜 | 狠狠艹夜夜艹 | 国产欧美一区二区精品仙草咪 |