97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产免费啪啪,人人草人人草,国产高清网址
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-NSE2/MMS21/HRP Conjugated antibody (bs-9544R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9544R-HRP
英文名稱 Rabbit Anti-NSE2/MMS21/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的E3連接酶MMS21蛋白抗體
別    名 C8orf36; E3 SUMO-protein ligase NSE2; hMMS21; hNSE2; methyl methanesulfonate sensitivity gene 21; MMS21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN; NSMCE2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞凋亡  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMS21/NSE2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex with six conserved nonSMC subunits, including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2. Specifically, this complex is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements. The NSE1 protein contains a RING-like motif that promotes DNA repair functions of the SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells. NSE2 stimulates sumoylation of SMC6 and the DNA repair protein TRAX. Depletion of the NSE2 protein by RNA interference leaves the cell vulnerable to DNA damage-induced apoptosis.

Function:
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Subunit:
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2.

Subcellular Location:
Nucleus.Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

Post-translational modifications:
Sumoylated, possibly via autosumoylation.

Similarity:
Belongs to the NSE2 family.
Contains 1 SP-RING-type zinc finger.

Database links:

Entrez Gene: 286053 Human

SwissProt: Q96MF7 Human

Unigene: 388297 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 好男人好资源在线观看免费视频 | 日日摸夜添夜夜夜添高潮 | 亚洲另类色区欧美日韩图片 | 中国美女a级毛片 | 欧美色欧美亚洲高清在线观看 | 亚洲国产AV天码精品果冻传媒 | 欧美操操操 | 国产欧美日产久久 | www.99色| 国产三级精品三级在专区 | 久久九九免费视频 | AV中文无码乱人伦在线观看 | 玩麻豆国产?片对白日逼视频 | 日韩人妻精品一区二区三区视频 | 欧美成人影片 | 99久久ER热在这里只有精品99 | 亚洲中文波霸中文字幕 | WWW国产亚洲精品久久 | 国产亚洲综合一区柠檬导航 | 久久中文字幕亚洲 | aV无码久久久久不卡蜜桃 | 蜜臀人妻精品一区二区免费 | 人妻少妇精品视频二区 | 日本熟妇色xxxxx | 欧美黄色免费影院 | 在线观看三级网站 | 亚洲精品www | 亚洲日韩一区精品射精 | 全免费午夜一级毛片真人 | 9久9久9久女女女九九九一九 | 欧美黄色a级 | 色呦呦久久久 | 蜜芽国产成人精品区 | 国产精品偷伦免费视频观看的 | 亚洲AV最新在线观看网址 | 学生在线精品一区二区 | 女人18毛片a级毛片免费视频 | 国产美女精品视频线免费播放软件 | 黄瓜视频入口永久免费观看 | 亚洲国产日韩a综合在线 | 午夜影院免费观看 |