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Rabbit Anti-Bestrophin 2/Gold Conjugated antibody (bs-11041R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11041R-Gold
英文名稱 Rabbit Anti-Bestrophin 2/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的卵黃狀黃斑病蛋白2抗體
別    名 BEST 2; Best disease Bestrophin; BEST2; Bestrophin2; FLJ20132; Vitelliform macular dystrophy 2 homolog; Vitelliform macular dystrophy 2 like 1; Vitelliform macular dystrophy 2 like protein 1; Vitelliform macular dystrophy; VMD2; VMD2 like gene 1; VMD2L1; BEST2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 腫瘤  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bestrophin 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.

Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Mainly confined to the retinal pigment epithelium and colon.

Similarity:
Belongs to the bestrophin family.

Database links:

Entrez Gene: 54831 Human

Entrez Gene: 212989 Mouse

Entrez Gene: 364973 Rat

Omim: 607335 Human

SwissProt: Q8NFU1 Human

SwissProt: Q6H1U9 Mouse

SwissProt: Q8BGM5 Mouse

Unigene: 435611 Human

Unigene: 215154 Mouse

Unigene: 31577 Mouse

Unigene: 136565 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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