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Rabbit Anti-Netrin G2/PE-Cy7 Conjugated antibody (bs-11103R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11103R-PE-Cy7
英文名稱 Rabbit Anti-Netrin G2/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的軸突生長誘向因子G2/神經突起生長導向因子G2抗體
別    名 Laminet 2; Laminet-2; Laminet2;Lmnt2; Lmnt 2; Lmnt-2; Netrin-G2; NetrinG2; NTNG1; NTNG 1; NTNG-1; NTNG2; NTNG 2; NTNG-2; NTNG2_HUMAN; bA479K20.1; LHLL9381.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 神經生物學  生長因子和激素  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Netrin G2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNC-6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient.

Function:
Promotes neurite outgrowth of both axons and dendrites.

Subunit:
Interacts with LRRC4 (By similarity).

Subcellular Location:
Cell membrane.

Post-translational modifications:
N-glycosylated (By similarity).

Similarity:
Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.

Database links:

Entrez Gene: 84628 Human

Entrez Gene: 171171 Mouse

Entrez Gene: 311836 Rat

SwissProt: Q96CW9 Human

SwissProt: Q8R4F1 Mouse

Unigene: 163642 Human

Unigene: 442448 Mouse

Unigene: 218540 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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