97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
欧美福利专区,91链接,av成人毛片
Rabbit Anti-RASSF5/BF488 Conjugated antibody (bs-11168R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-11168R-BF488
英文名稱 Rabbit Anti-RASSF5/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的RASSF5抗體
別    名 ras association domain-containing family protein 5; RASF5_HUMAN; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; RAPL; Nore1; Rapl.   
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RASSF5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.

Subunit:
Interacts directly with activated HRAS1; a RASSF5-STK4/MST1 complex probably associates with activated HRAS1. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS1. Isoform 2 interacts with activated RAP1A andITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Tissue Specificity:
Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.

Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-associating domain.
Contains 1 SARAH domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产精品三级 | 天天做天天爱天天综合网2021 | 久久好色视频 | 91精品国产综合久久久久久丝袜 | 国产精品视频色 | 中文无码亚洲精品字幕 | 欧美jizzhd精品欧美 | 18禁成年免费无码国产 | 免费在线观看h视频 | 天天爽狠狠噜天天噜日日噜 | 久久久久久91亚洲精品中文字幕 | 男女啪啪免费观看网站 | 性爱无码视频在线看 | 亚洲精品乱码久久久久膏 | 国产精品男人影院在线播放 | 国产一区二区三区不卡在线看 | 国产在线视频不卡一区二区 | 国产6区 | 伊人第一页 | 国产精品裸体一区二区三区 | 麻豆精品区 | 欧美极品视频 | 中文字幕日韩精品视频一区视频二区 | 成人国产一区二区三区精品麻豆 | 久久韩日 | 9797色| 在线观看欧美日韩国产 | 4hu四虎影视入口 | 在线观看色网 | JLZZJLZZ全部女高潮 | 欧美精品在线视频观看 | 日本黄色免费视频 | a在线免费 | 亚洲日韩爆乳中文字幕欧美 | av视屏在线| 色欲狠狠躁天天躁无码中文字幕 | 一本大道久久加勒比香蕉 | 男女一区二区三区 | 国产高潮流白浆喷水在线观看 | 中文字幕高清av | 久久久久国色AⅤ免费看 |