97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91性高湖久久久久久久久_久久99,亚洲伊人成无码综合网,国产色多传媒网站
Rabbit Anti-GRK6/Gold Conjugated antibody (bs-11235R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11235R-Gold
英文名稱 Rabbit Anti-GRK6/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的G蛋白偶聯(lián)受體激酶6抗體
別    名 GRK 6; GRK-6; G protein coupled receptor kinase 6; G protein coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; G-protein-coupled receptor kinase 6; Gprk6; Grk6; GRK6_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 心血管  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRK6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of Beta-adrenergic receptor kinase: GRK 2 (Beta ARK, Beta ARK1) and GRK 3 (Beta ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Function:
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain.

Database links:

Entrez Gene: 2870 Human

Entrez Gene: 26385 Mouse

Entrez Gene: 59076 Rat

Omim: 600869 Human

SwissProt: P43250 Human

SwissProt: O70293 Mouse

SwissProt: P97711 Rat

Unigene: 235116 Human

Unigene: 10193 Mouse

Unigene: 10633 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 99老色批| 国内精品免费久久久久软件 | 午夜在线免费观看视频 | 成人免费毛片内射美女-百度 | 国产精品无码免费视频二三区 | bt天堂在线www中文 | 性伦欧美刺激片在线观看 | 亚洲国产精品无码专区影院 | 日韩国产一区二区三区 | 成人免费视频软件网站 | 伊甸园精品区 | 国产亚洲综合一区柠檬导航 | 女人高潮一级一片 | 斗罗大陆3龙王传说第四季免费观看 | 国色天香免费视频日本 | 变形金刚之超能勇士免费观看 | 波多野结衣永久免费视频 | 日韩精品成人一区二区三区 | 一女多男两根同时进去性视频 | 亚洲精品无码一区二区三区 | 欧美一区在线视频 | 美女内射无套日韩免费播放 | 男人添女人下身视频高清 | 精品少妇的一区二区三区四区 | 成人一区二区三区久久精品嫩草 | 国产性AV在线 | 亚洲精品成人片在线播放4388 | 免费视频一二三 | 国产精品99久久不卡二区 | 国产精品欧美综合亚洲 | 99人人爽| 久久久久亚洲天堂 | 精品久久久久久 | 国产日韩视频在线播放 | 在线免费毛片视频 | 超碰超碰在线观看 | 国产一级一片免费播放 | 青青青青草视频 | 欢乐好声音1国语版免费观看 | 免费人成视频在线观看视频 | 欧美重口另类在线播放二区 |