97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
毛片高清视频,亚洲日本va中文字幕在线,日精品一区二区三区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-GRK6/Cy7 Conjugated antibody (bs-11235R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11235R-Cy7
英文名稱 Rabbit Anti-GRK6/Cy7 Conjugated antibody
中文名稱 Cy7標記的G蛋白偶聯受體激酶6抗體
別    名 GRK 6; GRK-6; G protein coupled receptor kinase 6; G protein coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; G-protein-coupled receptor kinase 6; Gprk6; Grk6; GRK6_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  信號轉導  激酶和磷酸酶  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRK6
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of Beta-adrenergic receptor kinase: GRK 2 (Beta ARK, Beta ARK1) and GRK 3 (Beta ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

Function:
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamin receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain.

Database links:

Entrez Gene: 2870 Human

Entrez Gene: 26385 Mouse

Entrez Gene: 59076 Rat

Omim: 600869 Human

SwissProt: P43250 Human

SwissProt: O70293 Mouse

SwissProt: P97711 Rat

Unigene: 235116 Human

Unigene: 10193 Mouse

Unigene: 10633 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产亚洲综合一区柠檬导航 | 国产精品久久久久久人妻精品 | 曰本人做爰大片免费观看 | 色吧av | 18勿看免费大片1000拍拍 | 亚洲精品午夜视频 | 麻豆国产一区二区三区 | 91久久精品国产免费一区 | 亚洲人成无码网站WWW | 精品国产肉丝袜久久 | 亚洲精品久久久久久中文传媒 | 午夜a级| 久久亚洲美女精品国产精品 | 麻豆安全免费网址入口 | 国产免费人成视频网站在线18 | 18禁成年免费无码国产 | sese综合 | 成人一区二区三区久久精品嫩草 | japan高清日本乱xxxxx | 999久久a精品合区久久久 | 日本老妇性视频 | 男人放进女人阳道动态图 | 欧美高清视频 | 天天干天天插天天 | av成人亚洲 | 韩日视频在线 | 欧美高潮喷水HD | 国产精品探花在线观看 | 午夜国产免费 | 国产精品久久久久久久久免费樱桃 | 亚洲精品在线观看视频 | 久国产精品视频 | 欧美一级鲁丝片 | 欧美色欧美亚洲高清在线观看 | 黄瓜视频入口永久免费观看 | 乱亲女h秽乱长久久久 | 无限看片的视频高清在线 | 日本高清com | 国产成人自拍视频在线 | 乱人伦人成品精国产在线 | 免费AV大片在线观看入口 |