97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
好吊妞视频这里只有精品,亚洲国产精品一区第二页,麻豆社区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RAB10/PE-Cy5.5 Conjugated antibody (bs-11257R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11257R-PE-Cy5.5
英文名稱 Rabbit Anti-RAB10/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的G蛋白結合蛋白RAB10抗體
別    名 GTP binding protein RAB10; Rab 10; Rab-10; RAB10 member RAS oncogene family; RAB10_HUMAN; Ras related GTP binding protein; Ras related GTP binding protein RAB10; Ras-related protein Rab-10.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 信號轉導  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Human, Rat, Chicken, Dog, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAB10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The Ras-related superfamily of guanine nucleotide binding proteins, which includes the Ral/Rec, Rap, R-Ras, and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21 (1). Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport (1,2). The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function (1-6). The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles (9). Several members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway (3-8).

Function:
The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation of transportvesicles to their fusion with membranes. Rabs cycle between aninactive GDP-bound form and an active GTP-bound form that is ableto recruit to membranes different set of downstream effectorsdirectly responsible for vesicle formation, movement, tethering andfusion (By similarity). That Rab is mainly involved in thebiosynthetic transport of proteins from the Golgi to the plasmamembrane. Regulates, for instance, SLC2A4/GLUT4 glucosetransporter-enriched vesicles delivery to the plasma membrane. Inparallel, it regulates the transport of TLR4, a toll-like receptorto the plasma membrane and therefore may be important for innateimmune response. Plays also a specific role in asymmetric proteintransport to the plasma membrane within the polarized neuron andepithelial cells. In neurons, it is involved in axonogenesisthrough regulation of vesicular membrane trafficking toward theaxonal plasma membrane while in epithelial cells, it regulatestransport from the Golgi to the basolateral membrane. Moreover, mayplay a role in the basolateral recycling pathway and in phagosomematuration. According to PubMed:23263280, may play a role inendoplasmic reticulum dynamics and morphology controllingtubulation along microtubules and tubules fusion. [ENZYME REGULATION] Rab activation is generally mediated by aguanine exchange factor (GEF), while inactivation throughhydrolysis of bound GTP is catalyzed by a GTPase activating protein(GAP) (By similarity). That Rab is activated by the DENND4C guanineexchange factor (GEF).

Subunit:
Interacts with MYO5A; mediates the transport to theplasma membrane of SLC2A4/GLUT4 storage vesicles. Interacts withGDI1 and maybe with GDI2; negatively regulates RAB10 associationwith membranes and activation. Interacts (GDP-bound form) withLLGL1; the interaction is direct and promotes RAB10 associationwith membranes and activation through competition with the Rabinhibitor GDI1 (By similarity). Interacts with EXOC4; probablyassociates with the exocyst (By similarity).

Subcellular Location:
Cytoplasmic vesicle membrane; Lipid-anchor(Probable); Cytoplasmic side (Probable). Golgi apparatus,trans-Golgi network membrane (By similarity). Endosome membrane.Recycling endosome membrane. Cytoplasmic vesicle, phagosomemembrane (By similarity). Cell projection, cilium. Endoplasmicreticulum membrane. Note=Associates with SLC2A4/GLUT4 storagevesicles. Localizes to the base of the cilium. Transientlyassociates with phagosomes (By similarity). According toPubMed:23263280 localizes to the endoplasmic reticulum at domainsof new tubule growth.

DISEASE:
Belongs to the small GTPase superfamily. Rab family.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:

Entrez Gene: 421994 Chicken

Entrez Gene: 403958 Dog

Entrez Gene: 19325 Mouse

Entrez Gene: 50993 Rat

SwissProt: P24409 Dog

SwissProt: P61027 Mouse

SwissProt: P35281 Rat

Unigene: 378993 Mouse

Unigene: 486858 Mouse

Unigene: 65864 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产不卡一区二区视频 | 国产精品综合久久久精品综合蜜臀 | 久久久久久久久一区二区三区 | 强壮的公次次弄得我高潮a片日本 | 蜜桃羞羞 | 麻豆一区二区三区视频 | 亚洲3级 | 一本久久综合亚洲鲁鲁五月天 | 色av色av色av | 无码H肉3D动漫在线观看 | 国产精品成人av | 在线观看免费日本 | 亚洲色就色成人综合网 | 国产一区二区免费在线观看 | 日韩毛片免费视频一级特黄 | 亚洲第一黄色网址 | 北条麻妃在线 | 国产精品中文字幕在线观看 | 亚洲国产成人精品女人久久久久 | 国产视频91在线 | 婷婷精品进入 | 久久字幕精品一区 | 篱笆女人狗电视连续剧第一部 | 91福利网站在线观看 | 97无码视频在线看视频 | 亚洲精品视频在线观看网站 | 扒开双腿猛进入喷水高潮叫声 | 久久精品一区中文字幕 | 欲望之岛在线免费观看 | 国产最顶级的黄色片在线免费观看 | 中文字幕第15页 | 一区二区免费在线观看视频 | 直接看片的av网址在线看片 | 无限看片的视频高清在线 | 欧洲在线一区二区 | av自拍偷拍| 日韩第九页 | 久久99久 | 午夜视频在线看 | 国产探花一区二区 | 国产又粗又大又黄AA片爱豆 |