97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
免费国产一区二区视频,欧美成人极品,青青青免费视频在线
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Dmrta1/BF350 Conjugated antibody (bs-11276R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11276R-BF350
英文名稱 Rabbit Anti-Dmrta1/BF350 Conjugated antibody
中文名稱 BF350標記的性發育轉錄因子蛋白DMO抗體
別    名 DMO; DMRT-like family A1; Dmrt4; DMRTA_HUMAN; Dmrta1; Doublesex- and mab-3-related transcription factor 4; Doublesex- and mab-3-related transcription factor A1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發育生物學  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41(h)/53(m)kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dmrta1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
DMRTA1 is a 504 amino acid protein that localizes to the nucleus and contains one DM DNA-binding domain. Expressed in prostate, liver, pancreas and kidney and present at lower levels in ovary and testis, DMRTA1 is thought to be involved in sexual developmental processes during maturation. The gene encoding DMRTA1 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Function:
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

Subcellular Location:
Nucleus.

Tissue Specificity:
Testis-specific.

DISEASE:
Defects in DMRT1 may be a cause of testicular germ cell tumor (TGCT) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
Defects in DMRT1 may be a cause of 46,XY sex reversal type 4 (SRXY4) [MIM:54230]. A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion.

Similarity:
Belongs to the DMRT family.
Contains 1 DM DNA-binding domain.

Database links:

Entrez Gene: 63951 Human

Entrez Gene: 242523 Mouse

Entrez Gene: 313352 Rat

Omim: 614803 Human

SwissProt: Q5VZB9 Human

SwissProt: A2AL09 Mouse

SwissProt: Q8CFG4 Mouse

Unigene: 371976 Human

Unigene: 130167 Mouse

Unigene: 43064 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲无码手机在线观看视频 | 视频第一区 | 91九色网址| 国产亚洲欧美日韩高清 | 少妇粉嫩小泬喷水视频WWW | 亚洲第一区精品 | 亚洲区精品3d国漫同人 | 午夜成年 | 欧美一区二区三区久久综合 | 玖玖精品 | www.操操操 | 狠狠色丁香婷婷综合久久来来去 | 国产成人无码一二三区视频 | 国产一级片| 天天干天天摸天天操 | 每日更新在线观看 | 91视频在线网站 | 美丽姑娘免费高清观看 | 免费无码又爽又刺激动态图 | 麻豆精品在线视频 | 国产v精品成人免费视频400条 | 人妻夫の上司犯感との中文字幕 | 久久久久久久久99精品情浪 | 国产裸体舞一区二区三区 | 好男人中文资源在线观看 | 欧美精品久久久久 | 四虎影视最新网站 | 北条一二三区 | 三级黄色的视频 | www久久综合| 久久精选| 日本人在线观看 | 日本在线播放 | 国产精品国产三级国AV在线观看 | 中文字幕在线一区二区三区 | 一体道色综合手机久久 | 亚洲精品久久久久中文字幕 | 欧美乱强伦XXXXX高潮 | 久国久产久精永久网页 | 精品91一区二区三区 | 亚洲韩国精品无码一区二区三区 |