97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产精品视频一区二区三区不卡,福利视频99,911国产香蕉
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-ESE1/APC Conjugated antibody (bs-11279R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11279R-APC
英文名稱 Rabbit Anti-ESE1/APC Conjugated antibody
中文名稱 APC標記的上皮細胞特異性轉錄因子1抗體
別    名 ELF3; E74 like factor 3; E74 like factor 3 ets domain transcription factor; E74 like factor 3 ets domain transcription factor epithelial specific; E74 like factor 3 ETS domain transcription factor serine box epithelial specific; E74-like factor 3; Elf3; ELF3_HUMAN; Epithelial restricted with serine box; Epithelial-restricted with serine box; Epithelium restricted Ets protein ESX; Epithelium specific Ets factor 1; Epithelium specific Ets transcription factor 1; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; EPR 1; EPR1; ERT; ESE-1; ESX; Ets domain transcription factor serine box; Ets domain transcription factor serine box epithelial specific; Ets transcription factor; ETS-related transcription factor Elf-3; jen; MGC139318.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 轉錄調節因子  細胞分化  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ESE1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
ESE-1, a member of the Ets family of transcription factors, critically regulates epithelial cell differentiation and mediates vascular inflammation. ESE-1 is strongly expressed in vascular endothelium and smooth muscle cells where it is induced in response to inflammatory cytokines and lipopolysaccharides, interacts with NF-KappaB to induce nitric oxide synthase, and is induced during terminal differentiation of epidermal and primary keratinocytes. In addition, ESE-1 is upregulated upon differentiation of corneal epithelium and interacts with Sp1 and AP-1 proteins to induce squamous differentiation marker expression in bronchial epithelial cells.

Function:
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

Subunit:
Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.

Subcellular Location:
Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.

Tissue Specificity:
Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.

Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Contains 1 PNT (pointed) domain.

Database links:

Entrez Gene: 1999 Human

Entrez Gene: 13710 Mouse

Entrez Gene: 304815 Rat

Omim: 602191 Human

SwissProt: P78545 Human

SwissProt: Q3UPW2 Mouse

SwissProt: Q4V7E1 Rat

Unigene: 67928 Human

Unigene: 441439 Mouse

Unigene: 3063 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩欧美在线综合 | 国产精品自在在线免费 | 久久高清中文字幕 | 天天躁日日躁狠狠躁2021a1 | 国产乱子伦视频大全 | 国产av一级片日韩二区 | 国产精品免费自拍 | 国产V精品V欧美V日韩V | 日日爱69 | 18禁无遮挡免费视频网站 | 亚洲人成网在线播放 | 无码人妻精一区二区三区 | 亚洲成人黄色在线观看 | 手机在线黄色网址 | 少妇撒尿一区二区在线视频 | 在线成人av | 亚洲资源网 | 麻豆传媒观看 | 每日更新在线观看 | 产精品视频在线观看免费 | 亚洲乱色熟女一区二区三区 | 欧美日韩一区免费 | 国产精品自在线拍亚洲另类 | av中文字幕在线观看第一页 | 国产在线精品免费 | 国产毛片精品 | 女人下边被添全过程A片图片 | 国产免费国产 | 国产骚熟 | 免费看日产一区二区三区 | 一区av在线 | 2222www色视频在线观看 | 日韩av综合中文字幕 | 草草在线免费视频 | 亚洲精品中文字幕乱码4区 一本一道波多野结衣av黑人 | 婷婷久久国产对白刺激五月99 | 免费国产女王调教在线视频 | jmcomic2最新安装包 | 久久一精品 | 精品视频在线观看一区 | 国产v精品成人免费视频400条 |