97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
www.色黄,色.www,亚洲国产精品久久久久久久久久
Rabbit Anti-Axin1/HRP Conjugated antibody (bs-2439R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2439R-HRP
英文名稱 Rabbit Anti-Axin1/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標(biāo)記的軸蛋白1抗體
別    名 AI316800; AXIN; Axin 1; Axin-1; axin1; AXIN1_HUMAN; Axis inhibition protein 1; Axis Inhibitor 1; Fu; fused; Fused, mouse, homolog of; hAxin; Kb; Ki; kinky; knobbly; MGC132911; MGC52315; PPP1R49; Protein Fused; Protein phosphatase 1 regulatory subunit 49.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Axin1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Function:
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. MACF1 is required for its translocation to cell membrane. On UV irradiation, translocates to the nucleus and colocalizes with DAAX.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Sumoylation at Lys-857 and Lys-860 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

DISEASE:
Defects in AXIN1 are involved in hepatocellular carcinoma (HCC) [MIM:114550].
Defects in AXIN1 are a cause of caudal duplication anomaly (CADUA) [MIM:607864]. Caudal duplication anomaly is characterized by the occurrence of duplications of different organs in the caudal region. Note=Caudal duplication anomaly is associated with hypermethylation of the AXIN1 promoter.

Similarity:
Contains 1 DIX domain.
Contains 1 RGS domain.

Database links:

Entrez Gene: 8312 Human

Entrez Gene: 395786 Chicken

Entrez Gene: 504357 Cow

Entrez Gene: 100065116 Horse

Entrez Gene: 12005 Mouse

Entrez Gene: 79257 Rat

Omim: 603816 Human

SwissProt: O42400 Chicken

SwissProt: O15169 Human

SwissProt: O35625 Mouse

SwissProt: O70239 Rat

Unigene: 592082 Human

Unigene: 23684 Mouse

Unigene: 31781 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.kastlife.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 日韩精品免费一区二区三区竹菊 | 久久香蕉国产线看观看6 | Chinese国产HD精品实拍 | 免费黄av | 无码av免费一区二区三区 | 国产精成人品日日拍夜夜免费 | 亚洲精品aⅴ中文字幕乱码 欧美日韩一区免费 | 麻豆www传媒入口 | 超碰人人草人人 | 永久免费黄色 | 激情综合色综合啪啪五月丁香搜索 | 伊人色亚洲 | 美女被久久久 | 少妇精品亚洲一区二区成人 | 裸体女人高潮毛片扒开一一区 | 国产又大又粗又爽的毛片 | 斗罗大陆4终极斗罗免费观看 | 久久艹视频 | 欧美激情精品久久 | 四虎影视www | 午夜dj高清www免费视频 | 久草视频精品 | 国产成人久久综合一区 | 国产97视频 | 爱情不设限免费观看 | 成人在线播放网站 | aaaa在线观看 | 欧美老妇视频热 | 国产亚洲精品A在线看 | 日韩国产一区二区三区 | 国产小视频免费观看 | 国产精品人人妻人人爽人人牛 | 亚洲成人欧美在线 | 精品成av人一区二区三区 | 日日射影院 | 男人操女人在线视频 | 青春草91| 免费黄色成年网站 | 蜜桃久久精品乱码一区二区 | 欧美一区二区三区少妇 | 欧美日韩中文字幕一区二区高清 |