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Rabbit Anti-GNRHR2/RBITC Conjugated antibody (bs-11403R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11403R-RBITC
英文名稱 Rabbit Anti-GNRHR2/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的促性腺素釋放激素受體2抗體
別    名 GnRH IIR; Putative gonadotropin-releasing hormone II receptor; gonadotropin-releasing hormone (type 2) receptor 2; GnRH-II-R; Type II GnRH receptor; GNRR2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  細胞膜受體  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Pig, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 33kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GNRHR2 (81-130aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.

Function:
Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Post-translational modifications:
Phosphorylated on the C-terminal cytoplasmic tail (Probable).

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:
UniProtKB/Swiss-Prot: Q96P88.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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