97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩精品一二区,色综合热,国产成人在线视频观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-AIP1/BF555 Conjugated antibody (bs-11705R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11705R-BF555
英文名稱 Rabbit Anti-AIP1/BF555 Conjugated antibody
中文名稱 BF555標記的激活素受體相互作用蛋白1抗體
別    名 Activin receptor interacting protein 1; Acvri1; Acvrinp1; ACVRIP1; AIP1; AIP 1; Aip-1; ARIP1; Atrophin 1 interacting protein 1; Atrophin 1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGI2; MAGI2_HUMAN; Membrane associated guanylate kinase 2; Membrane associated guanylate kinase inverted 2; Membrane associated guanylate kinase WW and PDZ domain containing 2; Membrane associated guanylate kinase WW and PDZ domain containing protein 2; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 2; S SCAM; SSCAM; WW and PDZ domain-containing protein 2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  細胞膜受體  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 159kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AIP1 (301-380aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.

Function:
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation.

Subunit:
Interacts (via its WW domains) with DRPLA. Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity). Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity). Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN.

Subcellular Location:
Cell junction, synapse, synaptosome (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Membrane-associated in synaptosomes (By similarity).

Tissue Specificity:
Specifically expressed in brain.

Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 6 PDZ (DHR) domains.
Contains 2 WW domains.

Database links:

Entrez Gene: 9863 Human

Omim: 606382 Human

SwissProt: Q86UL8 Human

Unigene: 603842 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 小香蕉影院 | 久久久二 | ccyy草草影院地址入口 | 日韩视频区 | 污污汅18禁在线无遮挡免费观看 | 亚洲av中文无码字幕色最 | 国产精品久久久亚洲女人 | 日本护士体内SHE精2╳╳╳ | 一本大道中文日本香蕉 | 亚洲女同一区 | 国产亚洲三区 | 久久久久无| 国产一区二区三区四区成男人 | 人妻三级日本三级日本三级极 | 欧美成人高清 | 91九色性视频 | 国产精品久久久久久久美男 | 欧美日韩色网专区 | 麻豆人妻无码性色av专区 | 欧美午夜精品一区二区蜜桃 | 国产又大又粗又爽的毛片 | 黄网站在线观 | 激情av无码后入 | 亚洲精品综合第一国产综合 | 欧美午夜精品一区二区蜜桃 | 91天仙tv国产福利精品 | 337p日本欧洲亚洲大胆艺术图 | 一区二区免费在线观看视频 | 精品人妻无码专区在中文字幕 | 涩涩亚洲乱码精品 | 18勿看免费大片1000拍拍 | 亚洲欧美中文日韩av一区 | 国产精品亚洲精品日韩已方 | yellow高清在线观看大全 | 国产免费一级大片 | 婷婷色一区 | 欧美一区二区三区 | 国产在线欧美日韩精品一区 | 无码男男肉片在线观看 | 久久亚洲精品成人无码网站夜色 | yellow高清免费观看日本 |