97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
heyzo朝桐光一区二区,伊人这里只有精品,国产人碰人摸人爱视频日日
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-CDK8/AP Conjugated antibody (bs-0570R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0570R-AP
英文名稱 Rabbit Anti-CDK8/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的周期素依賴性激酶8抗體
別    名 Cyclin Dependent Kinase 8; Cell Division Kinase 8; Cell division protein kinase 8; K35; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; CDK8_HUMAN; Cyclin-dependent kinase 8;.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質和核信號  信號轉導  細胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Chicken, Dog, Horse, Rabbit, Cat, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDK8
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008].

Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

Subunit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1.

Subcellular Location:
Nucleus (Probable).

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 1024 Human

Entrez Gene: 264064 Mouse

Omim: 603184 Human

SwissProt: P49336 Human

SwissProt: Q8R3L8 Mouse

Unigene: 382306 Human

Unigene: 260576 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 毛片一级网站 | 欧美国产成人精品二区芒果视频 | 蜜臀av免费一区二区三区久久乐 | 日本中文字幕在线免费观看视频 | 国产欧美另类久久久品 | 国产美女精品福利一区二区 | 国产精品女主播一区二区三区 | 国产日韩欧美一区 | 精品熟女碰碰人人A久久 | 国产无遮挡无码视频免费软件 | 亚洲日产色情偷拍 | a4yy欧美一区二区三区 | 一级黄色日本 | 狠狠躁夜夜a产精品视频 | 在线观看se | 日韩熟女精品一区二区三区 | 亚洲一区二区精品视频 | 欧美受xxxx黑人xyx爽 | 欧美亚洲小视频 | 色偷偷一区二区无码视频 | 亚洲3p激情在线观看 | 久久8888| 欧美精品乱码久久久久久 | 超碰97人人爱 | 天天玩天天操天天干 | 欧美日韩一区国产 | 91超碰人人做人人爽 | 精品无码一区二区三区在线 | 国产91精品一区二区三区四区 | 蜜芽国产成人精品区 | 97久久久久亚洲 | 久久久亚洲精品中文字幕 | 蜜桃av一区 | 色窝窝无码一区二区三区 | 成年人久久久 | 巨大欧美黑人XXXXBBBB | 国产在线精品一区二区三区 | 综合久久网 | 久久精品欧洲AV无码四区 | 日韩中文字幕一区二区三区 | 亚瑟在线精品视频 |