97久久久精品综合88久久_亚洲国产精品一_久热热国产久热_97操操操_北条麻妃在线免费观看_精品国自产拍天天拍

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
在线不卡国产,72家央企降薪名单最新公布,麻豆91茄子在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-Caldesmon (Ser789)/RBITC Conjugated antibody (bs-2082R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-2082R-RBITC
英文名稱 Rabbit Anti-phospho-Caldesmon (Ser789)/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的磷酸化鈣介質素抗體
別    名 Caldesmon (phospho-S789); Caldesmon (phospho-Ser789); p-Caldesmon (S789); p-Caldesmon (Ser789); p-Caldesmon (phospho-Ser789); CAD; CALD 1; CALD1; CALD1_HUMAN; Caldesmon 1; Caldesmon 1 Isoform 1; Caldesmon 1 Isoform 2; Caldesmon 1 Isoform 3; Caldesmon 1 Isoform 4; Caldesmon 1 Isoform 5; Caldesmon; Caldesmon1; CDM; H CAD; HCAD; L CAD; LCAD; MGC21352; NAG22.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 心血管  細胞生物  信號轉導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 93kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Caldesmon around the phosphorylation site of Ser789
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jul 2008].

Function:
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).

Tissue Specificity:
High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

Post-translational modifications:
In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).

Similarity:
Belongs to the caldesmon family.

Database links:

Entrez Gene: 800 Human

Entrez Gene: 109624 Mouse

Entrez Gene: 204926 Rat

Entrez Gene: 25687 Rat

Omim: 114213 Human

SwissProt: Q05682 Human

SwissProt: Q8VCQ8 Mouse

SwissProt: Q05682 Rat

Unigene: 490203 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.kastlife.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩欧美一区二区三区四区 | 精品国产欧美日韩不卡在线观看 | 精品无码黑人又粗又大又长 | 一区二区免费在线观看视频 | 久久久最新 | 中文字幕在线中文 | 少妇被爽到高潮动态图 | 欧美狂野乱码一二三四区 | 久久日韩精品一区鲁大师 | 欧美成人国产 | 柠檬福利第一导航在线 | 精品国产一区二区三区四区 | 女女女女bbbb毛片免费视频 | 日本三级美女 | 精品国产第一福利网站 | 久久av视频 | 色久悠悠在线观看 | 日韩精品人妻系列无码AV东京 | 亚洲国产AV天码精品果冻传媒 | 在线网址91 | 欧美精品无码久久久潘金莲 | 黄色A级国产免费大片 | 欧美色就插 | av高清| 欧美在线另类 | 亚洲性高清SUV | 亚洲国产一成久久精品 | 国产欧美日本一区二区三区 | 伊人久久大香线蕉AV五月天宝贝 | 国产精品白丝jk黑袜喷水视频 | 国产精选一区二区三区 | 逼自拍偷拍自拍天堂偷拍 | 偷窥国产亚洲免费视频 | 日韩午夜久久 | 逼特逼视频在线 | 91九色超碰 | 日韩在线 | 亚洲欧美一区二区在线观看 | 五月激情综合 | 久久九九国产精品 | 亚洲激情四射视频中文字幕久久 |